Acute disseminated encephalomyelitis epidemiology and demographics: Difference between revisions

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Revision as of 18:20, 13 November 2022

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sujaya Chattopadhyay, M.D.[2]

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Overview

The average annual incidence of ADEM is between 0.07 and 0.6 per 1,00,000 individuals per year. It is more common during childhood, with a median age on onset between 5-8 years and a male predominance (1.8:1).

Epidemiology and Demographics

Epidemiology

Average annual incidence is between 0.07 and 0.6 per 1,00,000 individuals per year^[1] ^[2]^[3].
Population-based studies revealed a slightly lower incidence in the US and UK compared to Asian countries. The incidence of pediatric ADEM varies between 0.47/100000 and 0.64/100000 in the Asian countries ^[2]^[3] compared to 0.07/100000 and 0.30/100000 in Europe and San Diego ^[3]^[4]^[5] .
The incidence seems to be increasing with the distance from the Equator^[6].

Demographics

ADEM is more common during childhood with a median age of onset between 5-8 years and a male predominance (1.8:1)^[7].
The adult age of presentation ranges from 33 to 41 years without any gender preference.
No specific ethnic distribution has been described.

References

↑ Xiong CH, Yan Y, Liao Z, Peng SH, Wen HR, Zhang YX; et al. (2014). "Epidemiological characteristics of acute disseminated encephalomyelitis in Nanchang, China: a retrospective study". BMC Public Health. 14: 111. doi:10.1186/1471-2458-14-111. PMC 3922734. PMID 24495742.
↑ ^2.0 ^2.1 Torisu H, Kira R, Ishizaki Y, Sanefuji M, Yamaguchi Y, Yasumoto S; et al. (2010). "Clinical study of childhood acute disseminated encephalomyelitis, multiple sclerosis, and acute transverse myelitis in Fukuoka Prefecture, Japan". Brain Dev. 32 (6): 454–62. doi:10.1016/j.braindev.2009.10.006. PMID 19942388.
↑ ^3.0 ^3.1 ^3.2 Pohl D, Hennemuth I, von Kries R, Hanefeld F (2007). "Paediatric multiple sclerosis and acute disseminated encephalomyelitis in Germany: results of a nationwide survey". Eur J Pediatr. 166 (5): 405–12. doi:10.1007/s00431-006-0249-2. PMID 17219129.
↑ Leake JA, Albani S, Kao AS, Senac MO, Billman GF, Nespeca MP; et al. (2004). "Acute disseminated encephalomyelitis in childhood: epidemiologic, clinical and laboratory features". Pediatr Infect Dis J. 23 (8): 756–64. doi:10.1097/01.inf.0000133048.75452.dd. PMID 15295226.
↑ Gudbjornsson BT, Haraldsson Á, Einarsdóttir H, Thorarensen Ó (2015). "Nationwide Incidence of Acquired Central Nervous System Demyelination in Icelandic Children". Pediatr Neurol. 53 (6): 503–7. doi:10.1016/j.pediatrneurol.2015.08.020. PMID 26463471.
↑ Pellegrino P, Radice S, Clementi E (2014). "Geoepidemiology of acute disseminated encephalomyelitis". Epidemiology. 25 (6): 928–9. doi:10.1097/EDE.0000000000000176. PMID 25265138.
↑ Tenembaum S, Chamoles N, Fejerman N (2002). "Acute disseminated encephalomyelitis: a long-term follow-up study of 84 pediatric patients". Neurology. 59 (8): 1224–31. doi:10.1212/wnl.59.8.1224. PMID 12391351.

[pmid24495742-1] Xiong CH, Yan Y, Liao Z, Peng SH, Wen HR, Zhang YX; et al. (2014). "Epidemiological characteristics of acute disseminated encephalomyelitis in Nanchang, China: a retrospective study". BMC Public Health. 14: 111. doi:10.1186/1471-2458-14-111. PMC 3922734. PMID 24495742.

[pmid19942388-2] 2.0 ^2.1 Torisu H, Kira R, Ishizaki Y, Sanefuji M, Yamaguchi Y, Yasumoto S; et al. (2010). "Clinical study of childhood acute disseminated encephalomyelitis, multiple sclerosis, and acute transverse myelitis in Fukuoka Prefecture, Japan". Brain Dev. 32 (6): 454–62. doi:10.1016/j.braindev.2009.10.006. PMID 19942388.

[pmid17219129-3] 3.0 ^3.1 ^3.2 Pohl D, Hennemuth I, von Kries R, Hanefeld F (2007). "Paediatric multiple sclerosis and acute disseminated encephalomyelitis in Germany: results of a nationwide survey". Eur J Pediatr. 166 (5): 405–12. doi:10.1007/s00431-006-0249-2. PMID 17219129.

[pmid15295226-4] Leake JA, Albani S, Kao AS, Senac MO, Billman GF, Nespeca MP; et al. (2004). "Acute disseminated encephalomyelitis in childhood: epidemiologic, clinical and laboratory features". Pediatr Infect Dis J. 23 (8): 756–64. doi:10.1097/01.inf.0000133048.75452.dd. PMID 15295226.

[pmid26463471-5] Gudbjornsson BT, Haraldsson Á, Einarsdóttir H, Thorarensen Ó (2015). "Nationwide Incidence of Acquired Central Nervous System Demyelination in Icelandic Children". Pediatr Neurol. 53 (6): 503–7. doi:10.1016/j.pediatrneurol.2015.08.020. PMID 26463471.

[pmid25265138-6] Pellegrino P, Radice S, Clementi E (2014). "Geoepidemiology of acute disseminated encephalomyelitis". Epidemiology. 25 (6): 928–9. doi:10.1097/EDE.0000000000000176. PMID 25265138.

[pmid12391351-7] Tenembaum S, Chamoles N, Fejerman N (2002). "Acute disseminated encephalomyelitis: a long-term follow-up study of 84 pediatric patients". Neurology. 59 (8): 1224–31. doi:10.1212/wnl.59.8.1224. PMID 12391351.

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@@ Line 1: / Line 1: @@
 __NOTOC__
 {{Acute disseminated encephalomyelitis}}
-{{CMG}}; {{AE}}{{SHM}}
+{{CMG}}; {{AE}}{{Sujaya}}
 {{PleaseHelp}}
 ==Overview==
-Average annual [[incidence]] of [[ADEM]] is between 0.07 and 0.6 per 1,00,000 individuals per year. It is more common during childhood with a median age on onset between 5-8 years and a male predominance (1.8:1).
+The average annual [[incidence]] of [[ADEM]] is between 0.07 and 0.6 per 1,00,000 individuals per year. It is more common during childhood, with a median age on onset between 5-8 years and a male predominance (1.8:1).
 ==Epidemiology and Demographics==
@@ Line 12: / Line 12: @@
 ===[[Epidemiology]]===
 *Average annual [[incidence]] is between 0.07 and 0.6 per 1,00,000 individuals per year<ref name="pmid24495742">{{cite journal| author=Xiong CH, Yan Y, Liao Z, Peng SH, Wen HR, Zhang YX | display-authors=etal| title=Epidemiological characteristics of acute disseminated encephalomyelitis in Nanchang, China: a retrospective study. | journal=BMC Public Health | year= 2014 | volume= 14 | issue=  | pages= 111 | pmid=24495742 | doi=10.1186/1471-2458-14-111 | pmc=3922734 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24495742  }} </ref> <ref name="pmid19942388">{{cite journal| author=Torisu H, Kira R, Ishizaki Y, Sanefuji M, Yamaguchi Y, Yasumoto S | display-authors=etal| title=Clinical study of childhood acute disseminated encephalomyelitis, multiple sclerosis, and acute transverse myelitis in Fukuoka Prefecture, Japan. | journal=Brain Dev | year= 2010 | volume= 32 | issue= 6 | pages= 454-62 | pmid=19942388 | doi=10.1016/j.braindev.2009.10.006 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19942388  }} </ref><ref name="pmid17219129">{{cite journal| author=Pohl D, Hennemuth I, von Kries R, Hanefeld F| title=Paediatric multiple sclerosis and acute disseminated encephalomyelitis in Germany: results of a nationwide survey. | journal=Eur J Pediatr | year= 2007 | volume= 166 | issue= 5 | pages= 405-12 | pmid=17219129 | doi=10.1007/s00431-006-0249-2 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17219129  }} </ref>.
-*Population based studies revealed a slightly lower [[incidence]] in the US and UK compared to Asian countries. The [[incidence]] of [[pediatric]] [[ADEM]] varies between 0.47/100000 and 0.64/100000 in the Asian countries <ref name="pmid19942388" /><ref name="pmid17219129" /> compared to 0.07/100000 and 0.30/100000 in Europe and San Diego <ref name="pmid17219129" /><ref name="pmid15295226">{{cite journal| author=Leake JA, Albani S, Kao AS, Senac MO, Billman GF, Nespeca MP | display-authors=etal| title=Acute disseminated encephalomyelitis in childhood: epidemiologic, clinical and laboratory features. | journal=Pediatr Infect Dis J | year= 2004 | volume= 23 | issue= 8 | pages= 756-64 | pmid=15295226 | doi=10.1097/01.inf.0000133048.75452.dd | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15295226  }}</ref><ref name="pmid26463471">{{cite journal| author=Gudbjornsson BT, Haraldsson Á, Einarsdóttir H, Thorarensen Ó| title=Nationwide Incidence of Acquired Central Nervous System Demyelination in Icelandic Children. | journal=Pediatr Neurol | year= 2015 | volume= 53 | issue= 6 | pages= 503-7 | pmid=26463471 | doi=10.1016/j.pediatrneurol.2015.08.020 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26463471  }}</ref> .
+*Population-based studies revealed a slightly lower [[incidence]] in the US and UK compared to Asian countries. The [[incidence]] of [[pediatric]] [[ADEM]] varies between 0.47/100000 and 0.64/100000 in the Asian countries <ref name="pmid19942388" /><ref name="pmid17219129" /> compared to 0.07/100000 and 0.30/100000 in Europe and San Diego <ref name="pmid17219129" /><ref name="pmid15295226">{{cite journal| author=Leake JA, Albani S, Kao AS, Senac MO, Billman GF, Nespeca MP | display-authors=etal| title=Acute disseminated encephalomyelitis in childhood: epidemiologic, clinical and laboratory features. | journal=Pediatr Infect Dis J | year= 2004 | volume= 23 | issue= 8 | pages= 756-64 | pmid=15295226 | doi=10.1097/01.inf.0000133048.75452.dd | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15295226  }}</ref><ref name="pmid26463471">{{cite journal| author=Gudbjornsson BT, Haraldsson Á, Einarsdóttir H, Thorarensen Ó| title=Nationwide Incidence of Acquired Central Nervous System Demyelination in Icelandic Children. | journal=Pediatr Neurol | year= 2015 | volume= 53 | issue= 6 | pages= 503-7 | pmid=26463471 | doi=10.1016/j.pediatrneurol.2015.08.020 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26463471  }}</ref> .
 * The [[incidence]] seems to be increasing with the distance from the Equator<ref name="pmid25265138">{{cite journal| author=Pellegrino P, Radice S, Clementi E| title=Geoepidemiology of acute disseminated encephalomyelitis. | journal=Epidemiology | year= 2014 | volume= 25 | issue= 6 | pages= 928-9 | pmid=25265138 | doi=10.1097/EDE.0000000000000176 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25265138  }}</ref>.