Acute disseminated encephalomyelitis other diagnostic studies: Difference between revisions
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{{Acute disseminated encephalomyelitis}} | {{Acute disseminated encephalomyelitis}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}} {{Sujaya}} | ||
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==Overview== | ==Overview== | ||
==Other Diagnostic Studies== | ==Other Diagnostic Studies== | ||
===Guided [[brain]] [biopsy]]<ref name="pmid21547392">{{cite journal| author=Hoche F, Pfeifenbring S, Vlaho S, Qirshi M, Theis M, Schneider W | display-authors=etal| title=Rare brain biopsy findings in a first ADEM-like event of pediatric MS: histopathologic, neuroradiologic and clinical features. | journal=J Neural Transm (Vienna) | year= 2011 | volume= 118 | issue= 9 | pages= 1311-7 | pmid=21547392 | doi=10.1007/s00702-011-0609-6 | pmc=3291843 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21547392 }} </ref>=== | |||
Many experts discourage [[diagnostic]] [[biopsies]] in absence of structured [[histopathological]] guidelines. Nevertheless, typical [[lesions]] of [[ADEM]] may be identified by [[histopathology]] anywhere in the [[white matter]] of [[brain]] and [[spinal cord]]. | |||
*[[Perivascular]] infiltration with [[macrophages]] and [[T cells]] with [[polymorphs]] in very early stages and no confluent [[demyelination]] | |||
*[[Astrocyte]] [[hyperplasia]] and [[gliosis]] in [[advanced]] stages | |||
==References== | ==References== |
Revision as of 09:59, 18 November 2022
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sujaya Chattopadhyay, M.D.[2]
Overview
Other Diagnostic Studies
Guided brain [biopsy]][1]
Many experts discourage diagnostic biopsies in absence of structured histopathological guidelines. Nevertheless, typical lesions of ADEM may be identified by histopathology anywhere in the white matter of brain and spinal cord.
- Perivascular infiltration with macrophages and T cells with polymorphs in very early stages and no confluent demyelination
- Astrocyte hyperplasia and gliosis in advanced stages
References
- ↑ Hoche F, Pfeifenbring S, Vlaho S, Qirshi M, Theis M, Schneider W; et al. (2011). "Rare brain biopsy findings in a first ADEM-like event of pediatric MS: histopathologic, neuroradiologic and clinical features". J Neural Transm (Vienna). 118 (9): 1311–7. doi:10.1007/s00702-011-0609-6. PMC 3291843. PMID 21547392.