Acute disseminated encephalomyelitis laboratory findings: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
===[[Antibodies]]=== | |||
===[[CSF]] studies=== | ===[[CSF]] studies=== | ||
*Non-specific [[lymphocytic]] [[pleocytosis]] and elevated [[albumin]] levels<ref name="pmid11376180">{{cite journal| author=Schwarz S, Mohr A, Knauth M, Wildemann B, Storch-Hagenlocher B| title=Acute disseminated encephalomyelitis: a follow-up study of 40 adult patients. | journal=Neurology | year= 2001 | volume= 56 | issue= 10 | pages= 1313-8 | pmid=11376180 | doi=10.1212/wnl.56.10.1313 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11376180 }} </ref> | *Non-specific [[lymphocytic]] [[pleocytosis]] and elevated [[albumin]] levels<ref name="pmid11376180">{{cite journal| author=Schwarz S, Mohr A, Knauth M, Wildemann B, Storch-Hagenlocher B| title=Acute disseminated encephalomyelitis: a follow-up study of 40 adult patients. | journal=Neurology | year= 2001 | volume= 56 | issue= 10 | pages= 1313-8 | pmid=11376180 | doi=10.1212/wnl.56.10.1313 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11376180 }} </ref> | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sujaya Chattopadhyay, M.D.[2]
Overview
Laboratory Findings
Antibodies
CSF studies
- Non-specific lymphocytic pleocytosis and elevated albumin levels[1]
- Transient [2] oligoclonal banding with a median frequency of 12.5% (range 0-29%)[3] in children and higher in the adult cases (37.5-58%)[2].
- Identification of the pathogen by specific cell-culture techniques or PCR[4][5]. The high prevalence of neurtropic viruses in the general population may lead to a spurious PCR result, making it difficult to prove a causal relation.
References
- ↑ Schwarz S, Mohr A, Knauth M, Wildemann B, Storch-Hagenlocher B (2001). "Acute disseminated encephalomyelitis: a follow-up study of 40 adult patients". Neurology. 56 (10): 1313–8. doi:10.1212/wnl.56.10.1313. PMID 11376180.
- ↑ 2.0 2.1 O'Riordan JI, Gomez-Anson B, Moseley IF, Miller DH (1999). "Long term MRI follow-up of patients with post infectious encephalomyelitis: evidence for a monophasic disease". J Neurol Sci. 167 (2): 132–6. doi:10.1016/s0022-510x(99)00160-4. PMID 10521553.
- ↑ Gupte G, Stonehouse M, Wassmer E, Coad NA, Whitehouse WP (2003). "Acute disseminated encephalomyelitis: a review of 18 cases in childhood". J Paediatr Child Health. 39 (5): 336–42. doi:10.1046/j.1440-1754.2003.00154.x. PMID 12887662.
- ↑ Fujimoto H, Asaoka K, Imaizumi T, Ayabe M, Shoji H, Kaji M (2003). "Epstein-Barr virus infections of the central nervous system". Intern Med. 42 (1): 33–40. doi:10.2169/internalmedicine.42.33. PMID 12583615.
- ↑ Riedel K, Kempf VA, Bechtold A, Klimmer M (2001). "Acute disseminated encephalomyelitis (ADEM) due to Mycoplasma pneumoniae infection in an adolescent". Infection. 29 (4): 240–2. doi:10.1007/s15010-001-1173-z. PMID 11545490.