Beta-thalassemia risk factors: Difference between revisions
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==Risk Factors== | ==Risk Factors== | ||
Family history and ancestry are factors that increase the risk of beta thalassemia. Depending on family history, if a person's parents or grandparents had beta thalassemia major or intermedia, there is a 75% (3 out of 4) probability of the mutated gene being inherited by an offspring. Even if a child does not have beta thalassemia major or intermedia, they can still be a carrier, possibly resulting in future generations of their offspring having beta thalassemia. | Family history and ancestry are factors that increase the risk of beta thalassemia. Depending on family history, if a person's parents or grandparents had beta thalassemia major or intermedia, there is a 75% (3 out of 4) probability of the mutated gene being inherited by an offspring. Even if a child does not have beta thalassemia major or intermedia, they can still be a carrier, possibly resulting in future generations of their offspring having beta thalassemia. | ||
Another risk factor is the ancestry. Beta thalassemia occurs most often in people of Italian, Greek, Middle Eastern, Southern Asian, and African ancestry<ref name=" | Another risk factor is the ancestry. Beta thalassemia occurs most often in people of Italian, Greek, Middle Eastern, Southern Asian, and African ancestry<ref name="pmid33626255">{{cite journal |vauthors=Taher AT, Musallam KM, Cappellini MD |title=β-Thalassemias |journal=N Engl J Med |volume=384 |issue=8 |pages=727–743 |date=February 2021 |pmid=33626255 |doi=10.1056/NEJMra2021838 |url=}}</ref>. | ||
Risk Factors in areas with high beta-thalassemia prevalence: | Risk Factors in areas with high beta-thalassemia prevalence: | ||
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*Limited resources for screening programs | *Limited resources for screening programs | ||
*Cultural and societal norms encouraging consanguineous marriage | *Cultural and societal norms encouraging consanguineous marriage | ||
*Consanguineous marriage in areas with a high prevalence of the disease | *Consanguineous marriage in areas with a high prevalence of the disease | ||
==References== | ==References== | ||
Revision as of 20:57, 31 July 2023
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Maryam Hadipour, M.D.[2]
Overview
Risk Factors
Family history and ancestry are factors that increase the risk of beta thalassemia. Depending on family history, if a person's parents or grandparents had beta thalassemia major or intermedia, there is a 75% (3 out of 4) probability of the mutated gene being inherited by an offspring. Even if a child does not have beta thalassemia major or intermedia, they can still be a carrier, possibly resulting in future generations of their offspring having beta thalassemia. Another risk factor is the ancestry. Beta thalassemia occurs most often in people of Italian, Greek, Middle Eastern, Southern Asian, and African ancestry[1].
Risk Factors in areas with high beta-thalassemia prevalence:
- Lack of awareness and education about the screening for beta-thalassemia
- Limited resources for screening programs
- Cultural and societal norms encouraging consanguineous marriage
- Consanguineous marriage in areas with a high prevalence of the disease