Beta-thalassemia risk factors: Difference between revisions
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Risk Factors in areas with high beta-thalassemia prevalence: | Risk Factors in areas with high beta-thalassemia prevalence: | ||
*Lack of awareness and education about the screening for beta-thalassemia | *Lack of awareness and education about the screening for beta-thalassemia<ref name="pmid18196920">{{cite journal |vauthors=Baig SM, Din MA, Hassan H, Azhar A, Baig JM, Aslam M, Anjum I, Farooq M, Hussain MS, Rasool M, Nawaz S, Qureshi JA, Zaman T |title=Prevention of beta-thalassemia in a large Pakistani family through cascade testing |journal=Community Genet |volume=11 |issue=1 |pages=68–70 |date=2008 |pmid=18196920 |doi=10.1159/000111641 |url=}}</ref> | ||
*Limited resources for screening programs | *Limited resources for screening programs | ||
*Cultural and societal norms encouraging consanguineous marriage | *Cultural and societal norms encouraging consanguineous marriage | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Maryam Hadipour, M.D.[2]
Overview
Risk Factors
Family history and ancestry are factors that increase the risk of beta thalassemia. Depending on family history, if a person's parents or grandparents had beta thalassemia major or intermedia, there is a 75% (3 out of 4) probability of the mutated gene being inherited by an offspring. Even if a child does not have beta thalassemia major or intermedia, they can still be a carrier, possibly resulting in future generations of their offspring having beta thalassemia. Another risk factor is the ancestry. Beta thalassemia occurs most often in people of Italian, Greek, Middle Eastern, Southern Asian, and African ancestry[1].
Risk Factors in areas with high beta-thalassemia prevalence:
- Lack of awareness and education about the screening for beta-thalassemia[2]
- Limited resources for screening programs
- Cultural and societal norms encouraging consanguineous marriage
- Consanguineous marriage in areas with a high prevalence of the disease
References
- ↑ Taher AT, Musallam KM, Cappellini MD (February 2021). "β-Thalassemias". N Engl J Med. 384 (8): 727–743. doi:10.1056/NEJMra2021838. PMID 33626255 Check
|pmid=value (help). - ↑ Baig SM, Din MA, Hassan H, Azhar A, Baig JM, Aslam M, Anjum I, Farooq M, Hussain MS, Rasool M, Nawaz S, Qureshi JA, Zaman T (2008). "Prevention of beta-thalassemia in a large Pakistani family through cascade testing". Community Genet. 11 (1): 68–70. doi:10.1159/000111641. PMID 18196920.