Beta-thalassemia history and symptoms: Difference between revisions
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*Loss of libido | *Loss of libido | ||
*Hormonal imbalances | *Hormonal imbalances | ||
*Cognitive problems Intermedia variant patients might experience moderate anemia, splenomegaly, bone changes, and intermittent need for blood transfusions at different ages | *Cognitive problems | ||
Intermedia variant patients might experience moderate anemia, splenomegaly, bone changes, and intermittent need for blood transfusions at different ages<ref name="pmid32557398">{{cite journal |vauthors=Motta I, Bou-Fakhredin R, Taher AT, Cappellini MD |title=Beta Thalassemia: New Therapeutic Options Beyond Transfusion and Iron Chelation |journal=Drugs |volume=80 |issue=11 |pages=1053–1063 |date=July 2020 |pmid=32557398 |doi=10.1007/s40265-020-01341-9 |url=}}</ref> | |||
==References== | ==References== | ||
Revision as of 20:17, 16 August 2023
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Maryam Hadipour, M.D.[2]
Overview
History and Symptoms
Major variant patients present in early infancy with:
- Severe anemia
- Failure to thrive
- Pallor
- Jaundice
- Fatigue
- Growth retardation
After treatment initiation, they would have symptoms of iron overload due to multiple transfusions which may cause:
- Fatigue and weakness
- Arthritis
- Abdominal pain
- Bronzed or grayish skin
- Loss of libido
- Hormonal imbalances
- Cognitive problems
Intermedia variant patients might experience moderate anemia, splenomegaly, bone changes, and intermittent need for blood transfusions at different ages[1]