Beta-thalassemia physical examination: Difference between revisions
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==Physical Examination== | ==Physical Examination== | ||
Physical findings in beta-thalassemia major may include<ref name="pmid32557398">{{cite journal |vauthors=Motta I, Bou-Fakhredin R, Taher AT, Cappellini MD |title=Beta Thalassemia: New Therapeutic Options Beyond Transfusion and Iron Chelation |journal=Drugs |volume=80 |issue=11 |pages=1053–1063 |date=July 2020 |pmid=32557398 |doi=10.1007/s40265-020-01341-9 |url=}}</ref>: | Physical findings in beta-thalassemia major may include<ref name="pmid32557398">{{cite journal |vauthors=Motta I, Bou-Fakhredin R, Taher AT, Cappellini MD |title=Beta Thalassemia: New Therapeutic Options Beyond Transfusion and Iron Chelation |journal=Drugs |volume=80 |issue=11 |pages=1053–1063 |date=July 2020 |pmid=32557398 |doi=10.1007/s40265-020-01341-9 |url=}}</ref><ref name="pmid34738740">{{cite journal |vauthors=Ali S, Mumtaz S, Shakir HA, Khan M, Tahir HM, Mumtaz S, Mughal TA, Hassan A, Kazmi SAR, Sadia, Irfan M, Khan MA |title=Current status of beta-thalassemia and its treatment strategies |journal=Mol Genet Genomic Med |volume=9 |issue=12 |pages=e1788 |date=December 2021 |pmid=34738740 |pmc=8683628 |doi=10.1002/mgg3.1788 |url=}}</ref>: | ||
*Pallor | *Pallor | ||
*Hyperpigmentation due to transfusion | *Hyperpigmentation due to transfusion | ||
Revision as of 23:09, 16 August 2023
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Maryam Hadipour, M.D.[2]
Overview
Physical Examination
Physical findings in beta-thalassemia major may include[1][2]:
- Pallor
- Hyperpigmentation due to transfusion
- Jaundice
- Hepatosplenomegaly
- Facial bone deformities
- Frontal bossing
- Long bone abnormalities
- Skull expansion with frontal, malar, and nasal bridge prominences
- Maxillary hypertrophy
- The upper maxillary expansion causes malocclusion by altering tooth spacing
- Short trunk and genu valgum
- Delayed sexual development
- low blood pressure which may indicate cardiac decompensation
- Irregular pulse due to iron-related myocardial abnormalities
References
- ↑ Motta I, Bou-Fakhredin R, Taher AT, Cappellini MD (July 2020). "Beta Thalassemia: New Therapeutic Options Beyond Transfusion and Iron Chelation". Drugs. 80 (11): 1053–1063. doi:10.1007/s40265-020-01341-9. PMID 32557398 Check
|pmid=value (help). - ↑ Ali S, Mumtaz S, Shakir HA, Khan M, Tahir HM, Mumtaz S, Mughal TA, Hassan A, Kazmi S, Sadia, Irfan M, Khan MA (December 2021). "Current status of beta-thalassemia and its treatment strategies". Mol Genet Genomic Med. 9 (12): e1788. doi:10.1002/mgg3.1788. PMC 8683628 Check
|pmc=value (help). PMID 34738740 Check|pmid=value (help). Vancouver style error: initials (help)