Beta-thalassemia natural history, complications and prognosis: Difference between revisions
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==Natural history== | ==Natural history== | ||
Untreated [[beta-thalassemia]] can also result in significant morbidity, mortality, and diminished quality of life. Patients with non-transfusion-dependent [[beta-thalassemia]] (NTD) can develop a wide range of complications in critical organ systems due to ineffective [[erythropoiesis]], [[hemolysis]], and primary [[iron overload]]. NTD patients can progress to transfusion-dependent beta-thalassemia (TD) later in life, which further exacerbates the risk of complications and [[iron overload]] | Untreated [[beta-thalassemia]] can also result in significant morbidity, mortality, and diminished quality of life. Patients with non-transfusion-dependent [[beta-thalassemia]] (NTD) can develop a wide range of complications in critical organ systems due to ineffective [[erythropoiesis]], [[hemolysis]], and primary [[iron overload]]. NTD patients can progress to transfusion-dependent beta-thalassemia (TD) later in life, which further exacerbates the risk of complications and [[iron overload]]<ref name="pmid34505291">{{cite journal |vauthors=Tang CH, Furnback W, Wang BCM, Tang J, Tang D, Lu MY, Huang VW, Musallam KM |title=Relationship between transfusion burden, healthcare resource utilization, and complications in patients with beta-thalassemia in Taiwan: A real-world analysis |journal=Transfusion |volume=61 |issue=10 |pages=2906–2917 |date=October 2021 |pmid=34505291 |pmc=9291481 |doi=10.1111/trf.16636 |url=}}</ref>. | ||
==Complications== | ==Complications== | ||
Revision as of 06:58, 25 August 2023
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Maryam Hadipour, M.D.[2]
Overview
Without regular blood transfusions, affected individuals by major beta-thalassemia typically develop severe anemia and related complications early in life, while beta-thalassemia intermedia patients would have a variable clinical course, complications, and prognosis. Beta-thalassemia minor subjects would not have significant symptoms, while in some cases might have an increased risk for iron deficiency anemia. Iron overload complications happen in transfusion-dependent thalassemia.
Natural history
Untreated beta-thalassemia can also result in significant morbidity, mortality, and diminished quality of life. Patients with non-transfusion-dependent beta-thalassemia (NTD) can develop a wide range of complications in critical organ systems due to ineffective erythropoiesis, hemolysis, and primary iron overload. NTD patients can progress to transfusion-dependent beta-thalassemia (TD) later in life, which further exacerbates the risk of complications and iron overload[1].
Complications
Prognosis
References
- ↑ Tang CH, Furnback W, Wang B, Tang J, Tang D, Lu MY, Huang VW, Musallam KM (October 2021). "Relationship between transfusion burden, healthcare resource utilization, and complications in patients with beta-thalassemia in Taiwan: A real-world analysis". Transfusion. 61 (10): 2906–2917. doi:10.1111/trf.16636. PMC 9291481 Check
|pmc=value (help). PMID 34505291 Check|pmid=value (help). Vancouver style error: initials (help)