Osteomyelitis

Osteomyelitis
Osteomyelitis in cancer. Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology
ICD-10	M86
ICD-9	730
DiseasesDB	9367
MedlinePlus	000437
eMedicine	ped/1677
MeSH	C01.539.160.495

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Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]

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Overview

Osteomyelitis is an infection of bone or bone marrow, usually caused by pyogenic bacteria or mycobacteria. It can be usefully subclassifed on the basis of the causative organism, the route, duration and anatomic location of the infection.

Etiology

Age group	Most common organisms
Newborns (younger than 4 mo)	S. aureus, Enterobacter species, and group A and B Streptococcus species
Children (aged 4 mo to 4 y)	S. aureus, group A Streptococcus species, Haemophilus influenzae, and Enterobacter species
Children, adolescents (aged 4 y to adult)	S. aureus (80%), group A Streptococcus species, H. influenzae, and Enterobacter species
Adult	S. aureus and occasionally Enterobacter or Streptococcus species

In children, the long bones are usually affected. In adults, the vertebrae and the pelvis are most commonly affected.

Acute osteomyelitis almost invariably occurs in children. When adults are affected, it may be because of compromised host resistance due to debilitation, intravenous drug abuse, infectious root-canaled teeth, or other disease or drugs (e.g. immunosuppressive therapy).

Osteomyelitis is a secondary complication in 1-3% of patients with pulmonary tuberculosis. In this case, the bacteria generally spread to the bone through the circulatory system, first infecting the synovium (due to its higher oxygen concentration) before spreading to the adjacent bone. In tubercular osteomyelitis, the long bones and vertebrae are the ones which tend to be affected.

Presentation

Generally microorganisms may be disseminated to bone hematogenously (i.e., via the blood stream), spread contiguously to bone from local areas of infection, such as cellulitis, or be introduced by penetrating trauma including iatrogenic causes such as joint replacements, internal fixation of fractures or root-canalled teeth. Leukocytes then enter the infected area, and in their attempt to engulf the infectious organisms, release enzymes that lyse bone. Pus spreads into the bone's blood vessels, impairing the flow, and areas of devitalized infected bone, known as sequestra, form the basis of a chronic infection. Often, the body will try to create new bone around the area of necrosis. The resulting new bone is often called an involucrum.

On histologic examination, these areas of necrotic bone are the basis for distinguishing between acute osteomyelitis and chronic osteomyelitis. Osteomyelitis is an infective process which encompasses all of the bone (osseous) components, including the bone marrow. When it is chronic it can lead to bone sclerosis and deformity.

Because of the particulars of their blood supply, the tibia, the femur, the humerus, the vertebra, the maxilla and the mandibular bodies are especially susceptible to osteomyelitis. [4]

Complete Differential Diagnosis of Associated Conditions

• Bacteroides
• Decubitus
• Diabetic angiopathy
• E.Coli
• Gastrointestinal infection
• Klebsiella
• Otitis
• Pneumonia
• Pseudomonas
• Serratia
• Sinusitis
• Skin infection
• Staphylococcus aureus
• Staphylococcus epidermidis
• Streptococcus pyogenes
• Streptococcus pneumoniae
• Tonsilitis
• Urinary tract infection
• Vasculitis

Diagnostic Findings

• Conventional radiographic evaluation of acute osteomyelitis is insufficient because bone changes are not evident for 14–21 days after the onset of infection.
• Although MR imaging is the accepted modality of choice for the early detection and surgical localization of osteomyelitis, in the emergency department, CT is usually more readily available for establishing the diagnosis.
• At CT, features of bacterial osteomyelitis include overlying soft-tissue swelling, periosteal reaction, medullary low-attenuation areas or trabecular coarsening, and focal cortical erosions.

MRI

Images courtesy of RadsWiki

Patient #1 Extensive calcaneal osteomyelitis. Note soft tissue ulceration and cellulitis

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  T1
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  STIR
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  T1
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  STIR
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  T1 fat sat contrast
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  T1 fat sat contrast

Bone Scan

Patient #2

Images courtesy of RadsWiki

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  Blood pool
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  Delayed

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Osteomyelitis and Chondritis of Vertebrae

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Treatment

Osteomyelitis often requires prolonged antibiotic therapy. IV antibiotics are generally used to combat the infection, with a course lasting a matter of weeks or months. A PICC line or central venous catheter is often placed for this purpose. Osteomyelitis also may require surgical debridement. Severe cases may lead to the loss of a limb. Initial first line antibiotic choice is determined by the patient's history and regional differences in common infective organisms.

Prior to the widespread availability and use of antibiotics, blow fly larvae were sometimes deliberately introduced to the wounds to feed on the infected material, effectively scouring clean.[5]

See also

• Brodie abscess

External Links

• Goldminer: Osteomyelitis

Additional Resources

• Template:MerckManual
• Template:Chorus

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