Ticagrelor: Difference between revisions
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== PLATO trial == | == PLATO trial == | ||
This trial, recently published in New England Journal of Medicine, has confirmed the superiority of ticagrelor over clopidogel in patients with acute coronary syndromes.<ref>{{cite journal|title=Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes|last=Wallentin|first=Lars|date=August 30, 2009 |journal=NEJM|url=http://content.nejm.org/cgi/content/full/NEJMoa0904327}}</ref> | This trial, recently published in New England Journal of Medicine, has confirmed the superiority of ticagrelor over clopidogel in patients with acute coronary syndromes.<ref>{{cite journal|title=Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes|last=Wallentin|first=Lars|date=August 30, 2009 |journal=NEJM|url=http://content.nejm.org/cgi/content/full/NEJMoa0904327}}</ref> | ||
==FDA Panel Review of Ticagrelor on July 28th, 2010== | |||
{{SIB}} | {{SIB}} |
Revision as of 17:11, 29 July 2010
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Routes of administration | oral |
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E number | {{#property:P628}} |
ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
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Formula | C23H28F2N6O4S |
Molar mass | 522.567 g/mol |
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WikiDoc Resources for Ticagrelor |
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Ongoing Trials on Ticagrelor at Clinical Trials.gov Clinical Trials on Ticagrelor at Google
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Overview
Ticagrelor (AZD6140) is a platelet aggregation inhibitor produced by AstraZeneca. As of February 2008, a clinical trial (PLATO: Platelet inhibition and patient outcomes) is comparing a combination of ticagrelor plus aspirin to clopidogrel plus aspirin for the prevention of thromboembolism.
Method of action
Like clopidogrel and ticlopidine, ticagrelor blocks ADP receptors of subtype P2Y12. In contrast to the other antiplatelet drugs, the blockage is reversible. Moreover, it does not need hepatic activation, which could reduce the risk of drug interactions.[1][2]
PLATO trial
This trial, recently published in New England Journal of Medicine, has confirmed the superiority of ticagrelor over clopidogel in patients with acute coronary syndromes.[3]
FDA Panel Review of Ticagrelor on July 28th, 2010
References
- ↑ H. Spreitzer (February 4, 2008). "Neue Wirkstoffe - AZD6140". Österreichische Apothekerzeitung (in German) (3/2008): 135. Check date values in:
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(help) - ↑ Owen, RT, Serradell, N, Bolos, J (2007). "AZD6140". Drugs of the Future. 32 (10): 845–853. doi:10.1358/dof.2007.032.10.1133832.
- ↑ Wallentin, Lars (August 30, 2009). "Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes". NEJM.
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