Patent ductus arteriosus causes: Difference between revisions

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==Causes==
==Causes==
Familial cases of PDA have been recorded, but a genetic cause has not been determined.


Chromosomal abnormalities are associated with persistent patency of the ductus arteriosus.  
*Genetic factors are thought to play a role in the some cases of patent ductus arteriosus. It has been found to occur with increased frequency in some families, indicating some association with autosomal dominant inheritence (17)Siblings of patients with PDA have been found to have an increased frequency.[16]. The exact gene location for patent ductus arteriosus has not yet been determined.  
*Congenital [[rubella]] (associated with PDA and [[pulmonary artery]] branch stenosis)
*[[fetal alcohol syndrome]]
*Maternal drug use
**[[amphetamine]]
**[[phenytoin]]


Implicated [[teratogens]] include congenital [[rubella]] (associated with PDA and [[pulmonary artery]] branch stenosis), maternal [[amphetamine]] use, maternal [[phenytoin]] use, and [[fetal alcohol syndrome]].


==References==
==References==

Revision as of 14:20, 19 July 2011

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Causes

  • Genetic factors are thought to play a role in the some cases of patent ductus arteriosus. It has been found to occur with increased frequency in some families, indicating some association with autosomal dominant inheritence (17)Siblings of patients with PDA have been found to have an increased frequency.[16]. The exact gene location for patent ductus arteriosus has not yet been determined.
  • Congenital rubella (associated with PDA and pulmonary artery branch stenosis)
  • fetal alcohol syndrome
  • Maternal drug use


References

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