Aortic stenosis causes: Difference between revisions

	Aortic Stenosis Microchapters
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Revision as of 14:30, 25 July 2011

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Associate Editors-In-Chief: Claudia P. Hochberg, M.D. [2]; Abdul-Rahman Arabi, M.D. [3]; Keri Shafer, M.D. [4]

Overview

Aortic stenosis can be categorized under two methods of causation: acquired and congenital. Research regarding the influence of preventative therapies on causation is mixed. More research is needed evaluating the role of preventative interventions, such as cholesterol lowering therapies, on the progression of disease onset.

Genetics

Congenital bicuspid valve is the most frequent form of congenital heart disease affecting approximately 1-2% of the population. 1/3rd of Supravalvular Aortic Stenosis cases are transmitted as an autosomal dominant trait as 60% of patients with supravalvular obstruction have Williams syndrome (supravalvular obstruction, intellectual impairment and facial abnormalities).

References

de:Aortenstenose (angeboren) no:Aortastenose nn:Aortastenose sv:Aortastenos

Template:WH

Template:WS

@@ Line 1: / Line 1: @@
-{{Aortic stenosis}}
+{{Template:Aortic stenosis}}
 {{CMG}}
-'''Associate Editors-In-Chief:''' Claudia P. Hochberg, M.D. [mailto:chochber@bidmc.harvard.edu]; [[User:Abdarabi|Abdul-Rahman Arabi, M.D.]] [mailto:abdarabi@yahoo.com]; [[User:KeriShafer|Keri Shafer, M.D.]] [mailto:kshafer@bidmc.harvard.edu]; [[Priyamvada Singh|Priyamvada Singh, MBBS]] [[mailto:psingh@perfuse.org]]
+'''Associate Editors-In-Chief:''' Claudia P. Hochberg, M.D. [mailto:chochber@bidmc.harvard.edu]; [[User:Abdarabi|Abdul-Rahman Arabi, M.D.]] [mailto:abdarabi@yahoo.com]; [[User:KeriShafer|Keri Shafer, M.D.]] [mailto:kshafer@bidmc.harvard.edu]
-'''Assistant Editor-In-Chief:''' [[Kristin Feeney|Kristin Feeney, B.S.]] [[mailto:kfeeney@perfuse.org]]
 ==Overview==
-Aortic stenosis can be categorized under two methods of causation: '''acquired''' and '''congenital'''. Research regarding the influence of preventative therapies on causation is mixed. More research is needed specifically looking at cholesterol lowering interventions and their role on disease onset.
+Aortic stenosis can be categorized under two methods of causation: '''acquired''' and '''congenital'''. Research regarding the influence of preventative therapies on causation is mixed. More research is needed evaluating the role of preventative interventions, such as cholesterol lowering therapies, on the progression of disease onset.
-==Causes==
-The etiology of Left-Sided Outflow Obstruction can be divided into two broad categories:
-#Acquired Aortic Stenosis and
-#Congenital Left-Sided Outflow Obstruction
-Major causes and predisposing conditions of aortic stenosis include [[acute rheumatic fever]] and [[bicuspid aortic valve]]. As individuals age, calcification of the [[aortic valve]] may occur and result in stenosis. This is especially likely to occur in people with a bicuspid aortic valve, but also occurs in the setting of perfectly normal valves as a result of age-induced 'wear and tear'. Typically, aortic stenosis due to calcification of a bicuspid valve occurs in the 4th of 5th decade of life, whereas symptomatic onset due to calcification of a normal valve tends to occur later - around the 7th or 8th decade.
-Of the various forms of aortic stenosis, the calcific type is predominant. Since calcific aortic stenosis shares many pathological features and risk factors with [[atherosclerosis]]. As atherosclerosis may be prevented and/or reversed by cholesterol lowering, there has been interest in attempting to modify the course of calcific aortic stenosis by cholesterol lowering with [[statin]] drugs. Although a number of small, [[observational studies]] demonstrated an association between lowered cholesterol and decreased progression, and even regression, of calcific aortic stenosis. A large [[randomized clinical trial]], published in 2005, failed to find any predictable effect of cholesterol lowering on calcific aortic stenosis. Researchers in 2007 study conversely demonstrated a slowing of aortic stenosis with the statin [[rosuvastatin]].<ref>{{cite journal |author=Moura LM, Ramos SF, Zamorano JL, ''et al'' |title=Rosuvastatin affecting aortic valve endothelium to slow the progression of aortic stenosis |journal=J. Am. Coll. Cardiol. |volume=49 |issue=5 |pages=554-61 |year=2007 |pmid=17276178 |doi=10.1016/j.jacc.2006.07.072}}</ref> More research is necessary to further clarify the specific mechanisms of disease onset and the influence of interventional methodologies on overall causation.
 ==Genetics==
@@ Line 24: / Line 13: @@
 {{reflist|2}}
+{{Circulatory system pathology}}
+{{Congenital malformations and deformations of circulatory system}}
 [[Category:DiseaseState]]
 [[Category:Signs and symptoms]]
@@ Line 30: / Line 21: @@
 [[Category:Cardiology]]
 [[Category:Congenital heart disease]]
-[[Category:Mature chapter]]
+[[de:Aortenstenose (angeboren)]]
 [[es:Estenosis aórtica]]
 [[fr:Rétrécissement aortique]]
+[[no:Aortastenose]]
+[[nn:Aortastenose]]
 [[pl:Stenoza Aortalnej]]
 [[pt:Estenose aórtica]]
 [[ro:Stenoza Aortică]]
+[[sv:Aortastenos]]
 [[tr:Aort darlığı]]
 {{WH}}
 {{WS}}

v t e Congenital malformations and deformations of circulatory system (Q20-Q28, 745-747)
Cardiac chambers and connections	Persistent truncus arteriosus - Double outlet right ventricle (Taussig-Bing syndrome) - Transposition of the great vessels (dextro, levo)
Cardiac septa	Ventricular septal defect - Atrial septal defect (Lutembacher's syndrome) - Atrioventricular septal defect (Ostium primum) - Tetralogy of Fallot - Eisenmenger's syndrome
Right: pulmonary and tricuspid valves	pulmonary valves (stenosis, insufficiency) - tricuspid valves (stenosis, atresia) - Ebstein's anomaly
Left: aortic and mitral valves	aortic valves (stenosis, insufficiency, bicuspid) - mitral valves (stenosis, regurgitation) - Hypoplastic left heart syndrome
Other congenital malformations of heart	Dextrocardia - Levocardia - Cor triatriatum
Great arteries	aorta (Patent ductus arteriosus, Aortic coarctation, Interrupted aortic arch, Overriding aorta, Aneurysm of sinus of Valsalva, Vascular ring) - Pulmonary atresia
Great veins	Persistent left superior vena cava - Total anomalous pulmonary venous connection - Scimitar syndrome
Other	Arteriovenous malformation (Cerebral arteriovenous malformation)
See also non-congenital conditions (I, 390-459)

Aortic stenosis causes: Difference between revisions

Revision as of 14:30, 25 July 2011

Overview

Genetics

References

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