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'''Transposition of the great vessels''' ('''TGV''') | '''Transposition of the great vessels''' ('''TGV''') | ||
*It refers to a group of [[congenital]] [[congenital heart defect|heart defects]] ('''CHD'''s) involving an abnormal spatial arrangement of any of the primary [[blood vessel|blood vessels]]: [[superior vena cava|superior]] and/or [[inferior vena cava|inferior]] [[vena cavae]] ('''SVC''', '''IVC'''), [[pulmonary artery]], [[pulmonary vein]]s, and [[aorta]]. | |||
*The clinical signs and symptoms associated with '''TGV''' may range from a change in [[blood pressure]] to an interruption in [[circulatory system|circulation]], depending on the nature and degree of the misplacement and which vessels are involved. | |||
*The term "TGV" is often used as a more specific reference to transposition of the great arteries TGA; however, TGA only relates to the [[aorta]] and the [[pulmonary artery]], whereas TGV is a broader term which can relate to these vessels as well as the [[SVC]], [[IVC]], and [[pulmonary veins]]. | |||
Most patients have an interatrial communication. Two-thirds have a [[patent ductus arteriosus]], and about one-third have a [[ventricular septal defect]] [[VSD]]. Stenosis, or other defects, of valves and/or vessels may also be present. | *In its strictest sense, transposition of vessels relates only to defects in which two or more vessels have "swapped" positions; in a broader sense, it may be taken to relate to any defect in which a vessel is in an abnormal position. | ||
*The terms TGV and TGA are most commonly used in reference to '''[[dextro-Transposition of the great arteries|dextro-TGA]]''' ('''d-TGA''') - in which the arteries ''are'' in swapped positions. | |||
*Both terms are also commonly used, though to a slightly lesser extent, in reference to '''[[Levo-Transposition of the great arteries|levo-TGA]]''' ('''l-TGA''') - in which both the arteries and the [[ventricle (heart)|ventricles]] are swapped; while other defects in this category are almost never referred to by either of these terms. | |||
*CHDs involving only the primary [[artery|arteries]] (pulmonary artery and aorta) belong to a sub-group called '''transposition of the great arteries''' ('''TGA'''). | |||
*In TGA, the hallmark is '''ventriculoarterial discordance''', in which the [[aorta]] (the main artery that carries blood to the body) arises from the morphologic [[right ventricle]] and the [[pulmonary artery]] (the artery that carries low oxygen blood to the [[lungs]]) arises from the morphologic [[left ventricle]]. This results in two separate and parallel circulations, which must communicate between them in order to survive after birth. | |||
*Most patients have an interatrial communication. Two-thirds have a [[patent ductus arteriosus]], and about one-third have a [[ventricular septal defect]] [[VSD]]. Stenosis, or other defects, of valves and/or vessels may also be present. | |||
*When no other heart defects are present it is called '''Simple TGV'''; when other defects are present it is called '''Complex TGV'''. | |||
==References== | ==References== |
Revision as of 18:36, 10 August 2011
Transposition of the great vessels Microchapters |
Classification |
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Differentiating Transposition of the great vessels from other Diseases |
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Transposition of the great vessels overview On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [2]; Cafer Zorkun, M.D., Ph.D. [3]; Keri Shafer, M.D. [4]; Assistant Editor(s)-In-Chief: Kristin Feeney, B.S. [5]
Overview
<youtube v=ZY11g3VZGVI/>
Transposition of the great vessels (TGV)
- It refers to a group of congenital heart defects (CHDs) involving an abnormal spatial arrangement of any of the primary blood vessels: superior and/or inferior vena cavae (SVC, IVC), pulmonary artery, pulmonary veins, and aorta.
- The clinical signs and symptoms associated with TGV may range from a change in blood pressure to an interruption in circulation, depending on the nature and degree of the misplacement and which vessels are involved.
- The term "TGV" is often used as a more specific reference to transposition of the great arteries TGA; however, TGA only relates to the aorta and the pulmonary artery, whereas TGV is a broader term which can relate to these vessels as well as the SVC, IVC, and pulmonary veins.
- In its strictest sense, transposition of vessels relates only to defects in which two or more vessels have "swapped" positions; in a broader sense, it may be taken to relate to any defect in which a vessel is in an abnormal position.
- The terms TGV and TGA are most commonly used in reference to dextro-TGA (d-TGA) - in which the arteries are in swapped positions.
- Both terms are also commonly used, though to a slightly lesser extent, in reference to levo-TGA (l-TGA) - in which both the arteries and the ventricles are swapped; while other defects in this category are almost never referred to by either of these terms.
- CHDs involving only the primary arteries (pulmonary artery and aorta) belong to a sub-group called transposition of the great arteries (TGA).
- In TGA, the hallmark is ventriculoarterial discordance, in which the aorta (the main artery that carries blood to the body) arises from the morphologic right ventricle and the pulmonary artery (the artery that carries low oxygen blood to the lungs) arises from the morphologic left ventricle. This results in two separate and parallel circulations, which must communicate between them in order to survive after birth.
- Most patients have an interatrial communication. Two-thirds have a patent ductus arteriosus, and about one-third have a ventricular septal defect VSD. Stenosis, or other defects, of valves and/or vessels may also be present.
- When no other heart defects are present it is called Simple TGV; when other defects are present it is called Complex TGV.