Thrombosis causes: Difference between revisions
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* Nature of the blood flow (hemostasis) | * Nature of the blood flow (hemostasis) | ||
The formation of a thrombus is usually caused by the top three causes, known as Virchow's triad. To elaborate, the pathogenesis includes: an injury to the vessel's wall (such as by trauma, infection, or turbulent flow at bifurcations) | The formation of a thrombus is usually caused by the top three causes, known as Virchow's triad. To elaborate, the pathogenesis includes: | ||
* an injury to the vessel's wall (such as by trauma, infection, or turbulent flow at bifurcations) | |||
* by the slowing or stagnation of blood flow past the point of injury (which may occur after long periods of sendentary behavior - for example, sitting on a long airplane flight | |||
* by a blood state of hypercoagulability (caused for example, by genetic deficiencies or autoimmune disorders). | |||
High altitude has also been known to induce thrombosis [http://dx.doi.org/10.1371/journal.pmed.0040290][http://www.mounteverest.net/news.php?news=16349]. Occasionally, abnormalities in [[coagulation]] are to blame. | High altitude has also been known to induce thrombosis [http://dx.doi.org/10.1371/journal.pmed.0040290][http://www.mounteverest.net/news.php?news=16349]. Occasionally, abnormalities in [[coagulation]] are to blame. |
Revision as of 13:43, 22 August 2011
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Associate Editors-in-Chief: Ujjwal Rastogi, MBBS [2]
Etiology
Classically, thrombosis is caused by abnormalities in one or more of the following (Virchow's triad):
- The composition of the blood (hypercoagulability)
- Quality of the vessel wall (endothelial cell injury)
- Nature of the blood flow (hemostasis)
The formation of a thrombus is usually caused by the top three causes, known as Virchow's triad. To elaborate, the pathogenesis includes:
- an injury to the vessel's wall (such as by trauma, infection, or turbulent flow at bifurcations)
- by the slowing or stagnation of blood flow past the point of injury (which may occur after long periods of sendentary behavior - for example, sitting on a long airplane flight
- by a blood state of hypercoagulability (caused for example, by genetic deficiencies or autoimmune disorders).
High altitude has also been known to induce thrombosis [3][4]. Occasionally, abnormalities in coagulation are to blame.
Intravascular coagulation follows, forming a structureless mass of red blood cells, leukocytes, and fibrin.
cs:Trombóza de:Thrombose eo:Trombozo it:Trombosi he:תרומבוס ms:Trombotik nl:Trombose fi:Verihiutale