Diabetes with hypertension medical therapy: Difference between revisions
(New page: {{Diabetes mellitus }} {{CMG}}; '''Associate Editor(s)-In-Chief:''' Priyamvada Singh, M.B.B.S. [mailto:psingh@perfuse.org]; {{CZ}} ==Overview== Hypertension is a comm...) |
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==Supportive trial data== | ==Supportive trial data== | ||
'''1)''' Study name - Fosinopril Versus Amlodipine Cardiovascular Events Randomized Trial (FACET), | '''1)''' Study name - [[Fosinopril Versus Amlodipine Cardiovascular Events Randomized Trial]] ('''[[FACET]]'''), 1998 | ||
'''2)''' Study design | '''2)''' Study design | ||
* Open label, randomized trial | |||
* 380 [[hypertension|hypertensive]] diabetics | |||
* | * [[Fosinopril]] (20 mg/day) or [[amlodipine]] (10 mg/day) | ||
* Follow up 3.5 years | |||
* Inclusion criteria- [[NIDDM]] and hypertension (SBP > 140 mmHg or DBP > 90 mmHg). | |||
* Exclusion criteria- History of [[coronary heart disease]] or [[stroke]], serum [[creatinine]] > 1.5 mg/dl, [[albuminuria]] > 40 micrograms/min, and use of lipid-lowering drugs, [[aspirin]], or antihypertensive agents other than [[beta-blocker]]s or [[diuretic]]s. | |||
'''3)''' Results- Fosinopril lowered the risk of the composite endpoints of acute myocardial infarction, stroke, or hospitalization due to angina more compared to amlodipine (hazards ratio = 0.49, 95% CI = 0.26-0.95). | '''3)''' Results- Fosinopril lowered the risk of the composite endpoints of acute [[myocardial infarction]], stroke, or hospitalization due to [[angina]] more compared to amlodipine (hazards ratio = 0.49, 95% CI = 0.26-0.95). | ||
==References== | ==References== | ||
Revision as of 14:47, 15 September 2011
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Diabetes mellitus Main page |
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Patient Information |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [2]; Cafer Zorkun, M.D., Ph.D. [3]
Overview
Hypertension is a common co-morbidity associated with patients of diabetes, especially type 2 diabetes. Proper management of both these conditions are important to prevent future chronic complications like cardiovascular, nephrology and other complications.
Supportive trial data
1) Study name - Fosinopril Versus Amlodipine Cardiovascular Events Randomized Trial (FACET), 1998
2) Study design
- Open label, randomized trial
- 380 hypertensive diabetics
- Fosinopril (20 mg/day) or amlodipine (10 mg/day)
- Follow up 3.5 years
- Inclusion criteria- NIDDM and hypertension (SBP > 140 mmHg or DBP > 90 mmHg).
- Exclusion criteria- History of coronary heart disease or stroke, serum creatinine > 1.5 mg/dl, albuminuria > 40 micrograms/min, and use of lipid-lowering drugs, aspirin, or antihypertensive agents other than beta-blockers or diuretics.
3) Results- Fosinopril lowered the risk of the composite endpoints of acute myocardial infarction, stroke, or hospitalization due to angina more compared to amlodipine (hazards ratio = 0.49, 95% CI = 0.26-0.95).