Thrombosis risk stratification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editors-in-Chief: Ujjwal Rastogi, MBBS [2]

Overview

Presence of a risk factor for thrombosis has an impact on the treatment of the patient. Short term anti-coagulation can be successful in the presence of a transient risk factor. Long term anti-coagulation is required in case of a persistent risk factor.

Risk factors

• General
  • Older age
  • Female gender
  • Smoking
  • Obesity
  • Pregnancy
  • Immobilization

• Medical
  • Surgery
  • Heart failure
  • Trauma
  • Oral contraceptive use
  • Varicose veins
  • Malignancy
  • Kidney disorders
  • Lupus anticoagulant
  • Paroxysmal nocturnal hemoglobinuria
  • Inflammatory bowel disease
  • Thromboangiitis obliterans
  • Disseminated intravascular coagulation

• Familial
  • Antithrombin III deficiency
  • Protein C deficiency/Protein S deficiency
  • APC resistance (Factor V Leiden)
  • Dysfibrogenemia
  • Hypoplasminogenemia
  • Familial homocysteinemia