Gliomatosis cerebri: Difference between revisions

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==Overview==
==[[Gliomatosis cerebri overview|Overview]]==
'''Gliomatosis cerebri (infiltrative diffuse astrocytosis)''' is a rare primary [[brain tumor]]. It is commonly characterized by diffuse infiltration of the brain with neoplastic [[glial cells]] that affect various areas of the cerebral lobes<ref>http://rad.usuhs.mil/medpix/radpix.html?mode=single&comebackto=mode%3Dgeo_browse&recnum=923</ref>.


While gliomatosis cerebri can occur at any age, it is generally found in the third and fourth decades of life. It may affect any part of the [[brain]] or even the [[spinal cord]], [[optic nerve]] and compact [[white matter]]. Clinical manifestations are indefinite, and include [[headache]], [[seizures]], visual disturbances, [[corticospinal tract]] deficits, [[lethargy]], and [[dementia]].
==[[Gliomatosis cerebri historical perspective|Historical Perspective]]==


Before the advent of [[MRI]], diagnosis was generally not established until [[autopsy]]. Even with MRI, however, diagnosis is difficult.<ref>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10696026&dopt=Abstract</ref> Typically, gliomatosis cerebri appears as a diffuse, poorly circumscribed, infiltrating non-enhancing lesion that is hyperintense on T2-weighted images and expands the cerebral white matter. It is difficult to distinguish from highly infiltrate anaplastic astrocytoma or [[Glioblastoma multiforme|GBM]].<ref>http://www.urmc.rochester.edu/smd/Rad/neurocases/Neurocase01.htm</ref> The prognosis for gliomatosis cerebri is generally poor, with a median survival time of only 12 months.<ref>http://www.childrenshospital.org/az/Site963/mainpageS963P0.html</ref> Surgery is not practical considering the extent of the disease, standard [[chemotherapy]] (nitrosourea) has been unsuccessful, and while brain irradiation can stabilize or improve neurologic function in some patients, its impact on survival has yet to be proven.{{Fact|date=February 2007}}
==[[Gliomatosis cerebri pathophysiology|Pathophysiology]]==
 
==[[Gliomatosis cerebri epidemiology and demographics|Epidemiology & Demographics]]==
 
==[[Gliomatosis cerebri risk factors|Risk Factors]]==
 
==[[Gliomatosis cerebri screening|Screening]]==
 
==[[Gliomatosis cerebri causes|Causes of Gliomatosis cerebri]]==
 
==[[Gliomatosis cerebri differential diagnosis|Differentiating Gliomatosis cerebri from other Diseases]]==
 
==[[Gliomatosis cerebri natural history|Natural History, Complications & Prognosis]]==
 
==Diagnosis==
[[Gliomatosis cerebri history and symptoms|History & Symptoms]] | [[Gliomatosis cerebri physical examination|Physical Examination]] | [[Gliomatosis cerebri laboratory tests|Lab Tests]] | [[Gliomatosis cerebri electrocardiogram|Electrocardiogram]] | [[Gliomatosis cerebri chest x ray|Chest X Ray]] | [[Gliomatosis cerebri CT|CT]] | [[Gliomatosis cerebri MRI|MRI]] | [[Gliomatosis cerebri echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Gliomatosis cerebri other imaging findings|Other Imaging Findings]] | [[Gliomatosis cerebri other diagnostic studies|Other Diagnostic Studies]]
 
==Treatment==
[[Gliomatosis cerebri medical therapy|Medical Therapy]] | [[Gliomatosis cerebri surgery|Surgery]] | [[Gliomatosis cerebri primary prevention|Primary Prevention]] | [[Gliomatosis cerebri secondary prevention|Secondary Prevention]] | [[Gliomatosis cerebri cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Gliomatosis cerebri future or investigational therapies|Future or Investigational Therapies]]


==References==
==References==
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{{Nervous tissue tumors}}
{{Nervous tissue tumors}}
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Revision as of 18:55, 18 January 2012

For patient information click here.

Gliomatosis cerebri
ICD-O: 9381/3
MeSH D018302

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Historical Perspective

Pathophysiology

Epidemiology & Demographics

Risk Factors

Screening

Causes of Gliomatosis cerebri

Differentiating Gliomatosis cerebri from other Diseases

Natural History, Complications & Prognosis

Diagnosis

History & Symptoms | Physical Examination | Lab Tests | Electrocardiogram | Chest X Ray | CT | MRI | Echocardiography or Ultrasound | Other Imaging Findings | Other Diagnostic Studies

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