Guillain-Barré syndrome laboratory tests: Difference between revisions
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* Stool culture for campylobacter jejuni (less frequent) | * Stool culture for campylobacter jejuni (less frequent) | ||
==Cerebrospinal analysis== | ==Cerebrospinal analysis== | ||
CSF is used almost every time to verify symptoms, but because of the acute nature of the disease, they may not become abnormal until after the first week of onset of signs and symptoms. | * CSF is used almost every time to verify symptoms, but because of the acute nature of the disease, they may not become abnormal until after the first week of onset of signs and symptoms. | ||
* '''[[cerebrospinal fluid|CSF]]''' - typical CSF findings include an elevated protein level (100 - 1000 mg/dL) without an accompanying pleocytosis (increased cell count). A sustained pleocytosis may indicate an alternative diagnosis such as infection. | * '''[[cerebrospinal fluid|CSF]]''' - typical CSF findings include an elevated protein level (100 - 1000 mg/dL) without an accompanying pleocytosis (increased cell count) (albuminocytological dissociation in the CSF). A sustained pleocytosis may indicate an alternative diagnosis such as infection. | ||
==Serology== | ==Serology== | ||
Revision as of 20:50, 24 February 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editors-In-Chief: Priyamvada Singh, MBBS [2]
Overview
Guillain-Barré syndrome (GBS) is usually diagnosed clinically. Lab tests are done to exclude other diagnosis and assess prognosis. The lab tests ordered are basic labs (CBC, ESR), lumbar puncture (GBS has characteristic albuminocytological dissociation), serological markers
Laboratory test
Routine labs
- Complete blood count + ESR (increased in inflammatory process)
- Serum electrolytes
- Liver function test
- Creatinine kinase increased in inflammation and myopathies
- Stool culture for campylobacter jejuni (less frequent)
Cerebrospinal analysis
- CSF is used almost every time to verify symptoms, but because of the acute nature of the disease, they may not become abnormal until after the first week of onset of signs and symptoms.
- CSF - typical CSF findings include an elevated protein level (100 - 1000 mg/dL) without an accompanying pleocytosis (increased cell count) (albuminocytological dissociation in the CSF). A sustained pleocytosis may indicate an alternative diagnosis such as infection.
Serology
- Less frequently done for campylobacter jejuni, CMV, EBV, HSV, HIV and mycoplasma pneumonia.
- Autoantibodies are only measured in case the diagnosis of GBS is uncertain. Antibodies to glycolipids, anti GM1 antibodies and Anti-GQ1b are increased.
Peripheral neuropathy panel
A panel of tests can be ordered in cases of diagnostic uncertainty with other peripheral neuropathies
- Thyroid profile (to rule out thyroid neuropathies)
- Erythrocyte sedimentation rate (ESR)increased in inflammatory process
- Rheumatology profiles
- Hemoglobin A1c for diabetic neuropathy
- Immunoelectrophoresis for serum protein (multiple myeloma)