Aminocaproic acid (injection): Difference between revisions
m (Protected "Aminocaproic acid": Protecting pages from unwanted edits ([edit=sysop] (indefinite) [move=sysop] (indefinite))) |
m (Bot: Automated text replacement (-{{SIB}} + & -{{EH}} + & -{{EJ}} + & -{{Editor Help}} + & -{{Editor Join}} +)) |
||
| Line 21: | Line 21: | ||
{{CMG}} | {{CMG}} | ||
'''Aminocaproic acid''' (also known as Amicar, є-amino caproic acid, or 6-aminohexanoic acid) is a derivative and analogue of the [[amino acid]] [[lysine]], which makes it an effective [[enzyme inhibitor|inhibitor]] for [[enzyme|enzymes]] which bind that particular residue. Such enzymes include [[proteolytic]] enzymes (which break down [[protein|proteins]]) including [[plasminogen]], the enzyme responsible for [[fibrinolysis]]. For this reason it is effective in treatment of some [[coagulopathy|bleeding disorders]] and is marketed as Amicar. | '''Aminocaproic acid''' (also known as Amicar, є-amino caproic acid, or 6-aminohexanoic acid) is a derivative and analogue of the [[amino acid]] [[lysine]], which makes it an effective [[enzyme inhibitor|inhibitor]] for [[enzyme|enzymes]] which bind that particular residue. Such enzymes include [[proteolytic]] enzymes (which break down [[protein|proteins]]) including [[plasminogen]], the enzyme responsible for [[fibrinolysis]]. For this reason it is effective in treatment of some [[coagulopathy|bleeding disorders]] and is marketed as Amicar. | ||
| Line 43: | Line 43: | ||
{{Antihemorrhagics}} | {{Antihemorrhagics}} | ||
[[Category:Amino acids]] | [[Category:Amino acids]] | ||
Revision as of 22:04, 8 August 2012
 | |
| Clinical data | |
|---|---|
| ATC code | |
| Pharmacokinetic data | |
| Metabolism | Renal |
| Elimination half-life | 2 hours |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| DrugBank | |
| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C6H13NO2 |
| Molar mass | 131.173 g/mol |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Aminocaproic acid (also known as Amicar, є-amino caproic acid, or 6-aminohexanoic acid) is a derivative and analogue of the amino acid lysine, which makes it an effective inhibitor for enzymes which bind that particular residue. Such enzymes include proteolytic enzymes (which break down proteins) including plasminogen, the enzyme responsible for fibrinolysis. For this reason it is effective in treatment of some bleeding disorders and is marketed as Amicar.
Mechanism of action
Aminocaproic acid works as an anti-fibrinolytic or anti-proteolytic. As a lysine analogue, it binds reversibly to the kringle domain of the enzyme plasminogen and blocks binding of fibrin, which is normally activated to plasmin.
Clinical use
Aminocaproic acid is used to treat excessive postoperative bleeding. It can be given orally or intravenously. One scenario where it may be useful is to treat bleeding after dental extractions in patients with hemophilia, because the oral mucosa is rich in plasminogen activators. A meta-analysis found that lysine analogs like aminocaproic acid significantly reduced blood loss in patients undergoing coronary artery bypass grafting.
Side effects
Its side effects are mainly related to the gastrointestinal tract and include nausea, vomiting, abdominal pain, and diarrhea. It may cause generalised myalgia. The main risk associated with aminocaproic acid is the increased risk for thrombosis because of the inhibition of fibrinolysis.
Other uses
Aminocaproic acid is occasionally used in BN-PAGE buffers, not for its effects as a proteolysis inhibitor, but to solubilize membrane proteins in place of sodium chloride (which is incompatible with PAGE in the necessary concentration). Percent recovery of protein complexes increases linearly with the concentration of inhibitor (between 125 mM and 750 mM)[1].
References
- ↑ Schägger, H and Von Jagow, G (1991). Blue Native Electrophoresis for Isolation of Membrane Protein Complexes in Enzymatically Active Form. Analytical Biochemistry 199 (2): 223-231.
- Pages with script errors
- E number from Wikidata
- ECHA InfoCard ID from Wikidata
- Articles without EBI source
- Chemical pages without ChemSpiderID
- Articles without KEGG source
- Articles without InChI source
- Articles without UNII source
- Drugs with no legal status
- Articles containing unverified chemical infoboxes
- Amino acids
- Antifibrinolytics
- Hematology