Cholestasis causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Causes

There are many causes of cholestasis.

Causes in Alphabetical Order

Aagenaes syndrome Alagille syndrome Alveolar hydatid disease Ascariasis Benign intrahepatic cholestasis Benoxaprofen Bile duct paucity in Graft-Versus-Host Disease Bile duct paucity, non syndromic form Bile duct stricture Biliary sludge Carcinoma of ampulla of Vater Caroli disease Chlorpromazine Cholangiocarcinoma Cholangitis Choledochal cyst Choledocholithiasis Cholelithiasis Cholestasis-pigmentary retinopathy-cleft palate Citrullinemia type 2 Clomipramine Clonazepam Clonorchiasis COACH syndrome Combined oral contraceptive pill Cystic fibrosis Diazepam Dubin-Johnson syndrome Erythromycin estolate Flucloxacillin Gallbladder cancer Glibenclamide Glimepiride Gold salts GRACILE syndrome Hepatic adenoma

Hepatic ductular hypoplasia Hepatocellular carcinoma Imipramine Indomethacin Intrahepatic cholestasis of pregnancy Klatskin tumor (bile duct bifurcation) Lathosterolosis Levomepromazine Liver metastases Long term intravenous nutrition Lorazepam Lutz-Richner and Landolt syndrome Mirizzi syndrome Mitochondrial DNA depletion syndrome, hepatocerebral form Nalidixic acid Neonatal diabetes-congenital hypothyroidism-congenital glaucoma-hepatic fibrosis-polycystic kidneys Nitrofurantoin North American Indian childhood cirrhosis Obesity due to pro-opiomelanocortin Deficiency Oxazepam Pancreatic cancer Para-amino salicylic acid Penicillamine Perazine Phenylbutazone Pipothiazine Primary biliary cirrhosis Primary sclerosing cholangitis Progressive familial intrahepatic cholestasis Proguanil Pyritinol Rifampicin Rotor syndrome Sarcoidosis Temazepam Zellweger spectrum

• Extrahepatic cholestasis occurs outside the liver. It can be caused by:

• Bile duct tumors
• Cysts
• Narrowing of the bile duct (strictures)
• Stones in the common bile duct
• Pancreatitis
• Pancreatic tumor or pseudocyst
• Pressure on an organ due to a nearby mass or tumor
• Primary sclerosing cholangitis

• Intrahepatic cholestasis occurs inside the liver. It can be caused by:

• Alcoholic liver disease
• Amyloidosis
• Bacterial abscess in the liver
• Being fed through a vein (IV)
• Lymphoma
• Intrahepatic cholestasis of pregnancy
• Primary biliary cirrhosis
• Primary sclerosing cholangitis
• Sarcoidosis
• Serious infections that have spread through the bloodstream (sepsis)
• Tuberculosis
• Viral hepatitis
• Sjogren syndrome

• Certain medications can also cause cholestasis.