Cardiomyopathy pathophysiology

Cardiomyopathy Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Pathophysiology

Gross Pathological Findings

Images shown below are courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology

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  Cardiomyopathy: Gross excellent view of mitral valve from left atrium anterior leaflet appears to balloon a bit into the atrium
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  Cardiomyopathy: Gross excellent view of mitral and tricuspid valves from atria, appear normal anatomy.

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  Cardiomyopathy: Gross apical slice of left and right ventricles concentric hypertrophy with cavitary obliteration sudden unexpected death obstructive cardiomyopathy
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  Dilated Cardiomyopathy: Gross natural color close-up view of heart surgically removed for a transplantation shows aortic valve and anterior leaflet of mitral valve with cholesterol deposits endocardium of left ventricle is diffusely thickened

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  Cardiomyopathy: Gross montage of ventricular slices showing hypertrophy and about normal ventricular lumen size a hypertrophic non-dilated cardiomyopathy
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  Cardiomyopathy: Gross ventricular slices hypertrophy and extensive myocardial fibrosis a unique case of global fiber disarray with atrophy and fibrosis

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  Cardiomyopathy: Gross close up view of a ventricle slice
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  Cardiomyopathy: Gross excellent ventricular slice with hypertrophy and fibrosis a unique case of global fiber disarray with hypertrophy then atrophy and then fibrosis

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  Cardiomyopathy: Gross external view of globular heart with patchy fibrosis seen through epicardium
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  Cardiomyopathy: Gross interventricular septum showing asymmetrical hypertrophy in posterior septum

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  Cardiomyopathy: Gross hypertrophic cardiomyopathy obstructive excellent section through left ventricle outlet to show subvalvular narrowing case of sudden death in a 27 yo male playing basketball no history of disease
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  Cardiomyopathy: Gross obstructive cardiomyopathy showing aorta outflow tract with marked endocardial thickening mitral valve appears normal (Same case as previous one)

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  Cardiomyopathy: Gross excellent view of mitral valve atrial surface showing thickening which is fibrous in body of valve and myxoid at area of free margin changes presumed secondary to insufficiency due to anterior motion
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  Cardiomyopathy: Gross dilated left ventricle with marked endocardial thickening this is what has been called adult fibroelastosis

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  Dilated Cardiomyopathy: Gross good example huge dilated left ventricle
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  Dilated Cardiomyopathy: Gross dilated left ventricle with marked endocardial sclerosis (an excellent example)

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  Cardiomyopathy: Gross intact globular shaped heart
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  Dilated Cardiomyopathy: Gross opened left ventricle dilated with endocardial thickening good example

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  Cardiomyopathy: Gross globular heart external view 10 year old girl with sickle cell anemia
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  Cardiomyopathy: Gross horizontal sections of ventricles dilation type 10 year old girl with sickle cell anemia

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  Cardiomyopathy: Intermediate between hypertrophic and dilated
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  Cardiomyopathy Asymmetrical Septal Hypertrophy

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  Dilated Cardiomyopathy: Gross opened globular left ventricle natural color (very good example)
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  Diabetic Cardiomyopathy: Gross natural color moderately hypertrophied heart shown in horizontal section hyperemic subendocardium has no microscopic lesion long standing type I diabetic patient, no significant coronary artery lesions, congestive heart failure

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  Brain: Infarct: Healing large MCA and PICA probably embolic 64 year old female chronic obstructive pulmonary disease and cardiomyopathy with atrial fibrillation
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  Kidney: Infarct Remote: Gross external view with capsule removed two old and very typical infarct scars 27yobf with dilated cardiomyopathy

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  Dilated Cardiomyopathy: Gross natural color external view globular heart 500 gm 24yo female seven pregnancies
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  Excessive pedal edema due to right heart failure in a patient with hypertrophic cardiomyopathy (due to functional aortic stenosis from narrow outflow tract)

Microscopic Pathological Findings

Images shown below are courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology

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  Cardiomyopathy: Micro H&E high mag excellent example myofiber disarray
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  Cardiomyopathy: Micro H&E low mag interventricular septum at junction of normal myofiber orientation with asymmetrical hypertrophy (an excellent example)

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  Cardiomyopathy: Micro trichrome low mag bizarre vacuolated fibers with disarray and focal fibrosis excellent low mag epicardial surface
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  Alcoholic Cardiomyopathy: Micro plastic section lipid in perinuclear area loss of myofibrils