Kaposi's sarcoma epidemiology and demographics: Difference between revisions
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Revision as of 19:08, 12 September 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Epidemiological Varieties
Classic KS As originally described was a relatively indolent disease affecting elderly men from the Mediterranean region, or of Eastern European Jewish descent.[1][2]
Endemic KS Was described later in young African people, mainly from sub-Saharan Africa, as a more aggressive disease which infiltrated the skin extensively, especially on the lower limbs. This, it should be noted, is unrelated to HIV infection.[3][4]
Transplant Related KS Had been described, but only rarely until the advent of calcineurin inhibitors (such as ciclosporin, which are inhibitors of T-cell function) for transplant patients in the 1980s, when its incidence grew rapidly.[5][6]
Epidemic KS Was described during the 1980s as an aggressive disease in AIDS patients (HIV also causes a defect in T-cell immunity). It is over 300 times more common in AIDS patients than in renal transplant recipients. [7]
Note that HHV-8 is responsible for all varieties of KS.
Demographics
References
- ↑ Iscovich, J (1998). "Classic Kaposi's sarcoma in Jews living in Israel, 1961-1989: a population-based incidence study". AIDS. 12 (15): 2067–72. Unknown parameter
|month=ignored (help) - ↑ Fenig, E (1998). "Classic Kaposi sarcoma: experience at Rabin Medical Center in Israel". Am J Clin Oncol. 21 (5): 498–500. Unknown parameter
|month=ignored (help) - ↑ Cook-Mozaffari, P (1998). "The geographical distribution of Kaposi's sarcoma and of lymphomas in Africa before the AIDS epidemic". Br J Cancer. 78 (11): 1521–8. Unknown parameter
|month=ignored (help) - ↑ Olsen, SJ (1998). "Increasing Kaposi's sarcoma-associated herpesvirus seroprevalence with age in a highly Kaposi's sarcoma endemic region, Zambia in 1985" (PDF). AIDS. 12 (14): 1921–5. Unknown parameter
|month=ignored (help) - ↑ Qunibi, W (1998). "Serologic association of human herpesvirus eight with posttransplant Kaposi's sarcoma in Saudi Arabia". Transplantation. 65 (4): 583–5. Unknown parameter
|month=ignored (help) - ↑ Luppi, Mario (2000). "Bone marrow failure associated with human herpesvirus 8 infection after transplantation". N Engl J Med. 343 (19): 1378–85. Unknown parameter
|month=ignored (help) - ↑ Beral, V (1990). "Kaposi's sarcoma among persons with AIDS: a sexually transmitted infection?". Lancet. 335 (8682): 123–8. Unknown parameter
|month=ignored (help)