Hairy cell leukemia pathophysiology: Difference between revisions
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Hairy cells are nearly mature, activated clonal cells with signs of VH gene differentiation.<ref>{{cite web |url=http://theoncologist.alphamedpress.org/cgi/content/full/11/7/780 |title=Hairy Cell Leukemia: An Elusive but Treatable Disease -- Wanko and de Castro 11 (7): 780 -- The Oncologist |accessdate=2007-09-10 |format= |work=}}</ref> They may be related to [[memory cells]]. | Hairy cells are nearly mature, activated clonal cells with signs of VH gene differentiation.<ref>{{cite web |url=http://theoncologist.alphamedpress.org/cgi/content/full/11/7/780 |title=Hairy Cell Leukemia: An Elusive but Treatable Disease -- Wanko and de Castro 11 (7): 780 -- The Oncologist |accessdate=2007-09-10 |format= |work=}}</ref> They may be related to [[memory cells]]. | ||
=== | ===Genetics=== | ||
While there are few [[Comparative genomic hybridization|genomic]] imbalances in the hairy cells, the [[expression]] of genes is dysregulated in a complex and specific pattern. The cells underexpress 3p24, 3p21, 3q13.3-q22, 4p16, 11q23, 14q22-q24, 15q21-q22, 15q24-q25, and 17q22-q24 and overexpress 13q31 and Xq13.3-q21.<ref>{{cite web |url=http://bloodjournal.hematologylibrary.org/cgi/content/abstract/bloodjournal;104/1/250 |title=Comparative expressed sequence hybridization studies of hairy cell leukemia show uniform expression profile and imprint of spleen signature -- Vanhentenrijk et al. 104 (1): 250 -- Blood |accessdate=2007-09-10 |format= |work=}}</ref> It has not yet been demonstrated that any of these changes have any practical significance to the patient. | While there are few [[Comparative genomic hybridization|genomic]] imbalances in the hairy cells, the [[expression]] of genes is dysregulated in a complex and specific pattern. The cells underexpress 3p24, 3p21, 3q13.3-q22, 4p16, 11q23, 14q22-q24, 15q21-q22, 15q24-q25, and 17q22-q24 and overexpress 13q31 and Xq13.3-q21.<ref>{{cite web |url=http://bloodjournal.hematologylibrary.org/cgi/content/abstract/bloodjournal;104/1/250 |title=Comparative expressed sequence hybridization studies of hairy cell leukemia show uniform expression profile and imprint of spleen signature -- Vanhentenrijk et al. 104 (1): 250 -- Blood |accessdate=2007-09-10 |format= |work=}}</ref> It has not yet been demonstrated that any of these changes have any practical significance to the patient. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
Hairy cells are nearly mature, activated clonal cells with signs of VH gene differentiation.[1] They may be related to memory cells.
Genetics
While there are few genomic imbalances in the hairy cells, the expression of genes is dysregulated in a complex and specific pattern. The cells underexpress 3p24, 3p21, 3q13.3-q22, 4p16, 11q23, 14q22-q24, 15q21-q22, 15q24-q25, and 17q22-q24 and overexpress 13q31 and Xq13.3-q21.[2] It has not yet been demonstrated that any of these changes have any practical significance to the patient.
References
- ↑ "Hairy Cell Leukemia: An Elusive but Treatable Disease -- Wanko and de Castro 11 (7): 780 -- The Oncologist". Retrieved 2007-09-10.
- ↑ "Comparative expressed sequence hybridization studies of hairy cell leukemia show uniform expression profile and imprint of spleen signature -- Vanhentenrijk et al. 104 (1): 250 -- Blood". Retrieved 2007-09-10.