Aggressive NK-cell leukemia history and symptoms: Difference between revisions
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==History and Symptoms== | ==History and Symptoms== | ||
Patients usually present with constitutional symptoms ([[malaise]], [[weight loss]], [[fatigue (medical)|fatigue]]), and [[hepatosplenomegaly]] is commonly found on physical exam. [[Lymphadenopathy]] is also found to a lesser extent. Due to the aggressive nature of the disease, patients may initially present at a more advanced stage, with [[coagulopathies]], hemophagocytic syndrome, and multi-organ failure. | Patients usually present with constitutional symptoms ([[malaise]], [[weight loss]], [[fatigue (medical)|fatigue]]), and [[hepatosplenomegaly]] is commonly found on physical exam. [[Lymphadenopathy]] is also found to a lesser extent. Due to the aggressive nature of the disease, patients may initially present at a more advanced stage, with [[coagulopathies]], hemophagocytic syndrome, and multi-organ failure.<ref name="kob1"> | ||
[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=8854571&query_hl=29&itool=pubmed_ExternalLink] | [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=8854571&query_hl=29&itool=pubmed_ExternalLink] | ||
Kobayashi Y, Uehara S, Inamori K, Shirato R, Ozawa K, Sklar J, Asano S. "Hemophagocytosis as a para-neoplastic syndrome in NK cell leukemia." '''Int J Hematol'''. 1996 Aug;64(2):135-42. PMID: 8854571</ref><ref name="oku1">[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=1746541&query_hl=31&itool=pubmed_ExternalLink] | Kobayashi Y, Uehara S, Inamori K, Shirato R, Ozawa K, Sklar J, Asano S. "Hemophagocytosis as a para-neoplastic syndrome in NK cell leukemia." '''Int J Hematol'''. 1996 Aug;64(2):135-42. PMID: 8854571</ref><ref name="oku1">[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=1746541&query_hl=31&itool=pubmed_ExternalLink] | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3]
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Overview
History and Symptoms
Patients usually present with constitutional symptoms (malaise, weight loss, fatigue), and hepatosplenomegaly is commonly found on physical exam. Lymphadenopathy is also found to a lesser extent. Due to the aggressive nature of the disease, patients may initially present at a more advanced stage, with coagulopathies, hemophagocytic syndrome, and multi-organ failure.[1][2]
References
- ↑ [1] Kobayashi Y, Uehara S, Inamori K, Shirato R, Ozawa K, Sklar J, Asano S. "Hemophagocytosis as a para-neoplastic syndrome in NK cell leukemia." Int J Hematol. 1996 Aug;64(2):135-42. PMID: 8854571
- ↑ [2] Okuda T, Sakamoto S, Deguchi T, Misawa S, Kashima K, Yoshihara T, Ikushima S, Hibi S, Imashuku S. "Hemophagocytic syndrome associated with aggressive natural killer cell leukemia." Am J Hematol. 1991 Dec;38(4):321-3. PMID: 1746541