Cryoglobulinemia history and symptoms

Cryoglobulinemia Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Cryoglobulinemia from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X Ray
CT
MRI
Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Cryoglobulinemia history and symptoms On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Cryoglobulinemia history and symptoms All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Cryoglobulinemia history and symptoms
CDC on Cryoglobulinemia history and symptoms
Cryoglobulinemia history and symptoms in the news
Blogs on Cryoglobulinemia history and symptoms
Directions to Hospitals Treating Cryoglobulinemia
Risk calculators and risk factors for Cryoglobulinemia history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]

Please help WikiDoc by adding more content here. It's easy! Click here to learn about editing.

Symptoms

• Palpable purpura, arthralgias, and neuropathy are common findings.
• Nonspecific systemic complaints, hepatosplenomegaly and hypocomplementemia are noted.
• Low-grade Non-Hodgkins lymphomas may occur with increased frequency among these patients.
• Renal disease occurs in 20% of patients at diagnosis and eventually develops in up to 60%, usually after the development of purpura.

  • Renal involvement is more common in Type II than Type III MC.
  • Most patients present with ayamptomatic hematuria and poteinuria, but frank nephrotic syndrome and acute renal failure can develop.

• The characteristic findings on renal biopsy are

  1. Intraluminal thrombi
  2. Diffuse IgM deposition in the capillary loops
  3. Subendothelial deposits in a “curvilinear” pattern on EM.

• Only 14% develop end stage renal disease (ESRD) at 10 years after a renal biopsy demonstrates MC.
• Recurrent MC can affect up to 70% of transplanted kidneys, but does not preclude transplantation since most of these grafts do not fail.

References

Template:WikiDoc Sources