Cryoglobulinemia laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]

Laboratory Findings

Electrolyte and Biomarker Studies

• At least 20cc of blood should be drawn in the fasting state (lipids interfere) and sent to the lab in warm water.

  • The blood is spun at body temperature then the serum is cooled to see if a precipitate develops.

    • “Cryocrits” of up to 50% have been noted.

  • The cryoprecipitates is then analyzed for type of immune complex by immunofixation.
  • If anti-HCV and HCV RNA are negative but hepatits C is still suspected, the cryoprecipitate can be assayed directly for HCV RNA and anti-HCV antibody.
  • Spurious leukocytosis and thrombocytosis from the cryoglobulin particles have been noted if the sample is tested a lower temperature.
  • White blood cell count (WBC) of >40K normalize with warming of the blood.

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