Cryoglobulinemia other diagnostic studies: Difference between revisions
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== Other Diagnostic Studies == | == Other Diagnostic Studies == | ||
===Skin Biopsy=== | |||
Skin biopsy can be of value in establishing the diagnosis. | |||
===Renal Biopsy=== | |||
* The characteristic findings on renal biopsy are | |||
*:# Intraluminal thrombi | |||
*:# Diffuse [[IgM]] deposition in the capillary loops | |||
*:# Subendothelial deposits in a “curvilinear” pattern on EM. | |||
* Only 14% develop end stage renal disease ([[ESRD]]) at 10 years after a renal biopsy demonstrates MC. | |||
* Recurrent MC can affect up to 70% of transplanted kidneys, but does not preclude transplantation since most of these grafts do not fail. | |||
==References== | ==References== | ||
Revision as of 13:16, 21 September 2012
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Cryoglobulinemia Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]
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Overview
Other Diagnostic Studies
Skin Biopsy
Skin biopsy can be of value in establishing the diagnosis.
Renal Biopsy
- The characteristic findings on renal biopsy are
- Intraluminal thrombi
- Diffuse IgM deposition in the capillary loops
- Subendothelial deposits in a “curvilinear” pattern on EM.
- Only 14% develop end stage renal disease (ESRD) at 10 years after a renal biopsy demonstrates MC.
- Recurrent MC can affect up to 70% of transplanted kidneys, but does not preclude transplantation since most of these grafts do not fail.