Pernicious anemia causes: Difference between revisions
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==Overview== | |||
==Causes== | |||
Most commonly, the cause for impaired binding of vitamin B<sub>12</sub> by intrinsic factor is [[autoimmune]] [[atrophic gastritis]], in which [[autoantibody|autoantibodies]] are directed against [[parietal cell|parietal cells]] (resulting in their loss) as well as against the [[intrinsic factor]] itself (rendering it unable to bind vitamin B<sub>12</sub>). Less frequently, loss of parietal cells may simply be part of a widespread atrophic gastritis of non-autoimmune origin, such as that frequently occurring in elderly people affected with long-standing chronic [[gastritis]] of any cause (including [[Helicobacter pylori]] infection). Note that forms of vitamin B<sub>12</sub> deficiency other than pernicious anaemia must be considered in the [[differential diagnosis]] of [[megaloblastic anaemia]]. | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 18:09, 21 September 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Causes
Most commonly, the cause for impaired binding of vitamin B12 by intrinsic factor is autoimmune atrophic gastritis, in which autoantibodies are directed against parietal cells (resulting in their loss) as well as against the intrinsic factor itself (rendering it unable to bind vitamin B12). Less frequently, loss of parietal cells may simply be part of a widespread atrophic gastritis of non-autoimmune origin, such as that frequently occurring in elderly people affected with long-standing chronic gastritis of any cause (including Helicobacter pylori infection). Note that forms of vitamin B12 deficiency other than pernicious anaemia must be considered in the differential diagnosis of megaloblastic anaemia.