Pernicious anemia laboratory findings: Difference between revisions
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{{Pernicious anemia}} | {{Pernicious anemia}} | ||
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==Overview== | |||
==Laboratory Findings== | |||
A diagnosis of pernicious anaemia first requires demonstration of [[megaloblastic anaemia]] (through a [[full blood count]]) and of its direct cause, vitamin B{{ssub|12}} deficiency (by measuring B{{ssub|12}} levels in serum). A [[Schillings test]] can then be used to distinguish pernicious anemia from other causes of vitamin B{{ssub|12}} deficiency (notably [[malabsorption]]. A diagnosis of [[atrophic gastritis]] should be confirmed by [[gastroscopy]] with [[biopsy|biopsies]]. Approximately 90% of individuals with pernicious anemia have antibodies for parietal cells, however only 50% of individuals with these antibodies have pernicious anaemia. | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 18:13, 21 September 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Laboratory Findings
A diagnosis of pernicious anaemia first requires demonstration of megaloblastic anaemia (through a full blood count) and of its direct cause, vitamin BTemplate:Ssub deficiency (by measuring BTemplate:Ssub levels in serum). A Schillings test can then be used to distinguish pernicious anemia from other causes of vitamin BTemplate:Ssub deficiency (notably malabsorption. A diagnosis of atrophic gastritis should be confirmed by gastroscopy with biopsies. Approximately 90% of individuals with pernicious anemia have antibodies for parietal cells, however only 50% of individuals with these antibodies have pernicious anaemia.