Endometrial cancer pathophysiology: Difference between revisions
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[[Image:Endometrial adenocarcinoma (1).jpg|thumb|left|Endometrial adenocarcinoma]] | [[Image:Endometrial adenocarcinoma (1).jpg|thumb|left|Endometrial adenocarcinoma]] | ||
====Microscopic pathology==== | ====Microscopic pathology==== | ||
The histopathology of endometrial cancers is highly diverse. The most common finding is a ''well-differentiated endometrioid adenocarcinoma'', which is composed of numerous, small, crowded glands with varying degrees of nuclear atypia, mitotic activity, and stratification. This often appears on a background of endometrial hyperplasia. Frank adenocarcinoma may be distinguished from atypical hyperplasia by the finding of clear stromal invasion, or "back-to-back" glands which represent nondestructive replacement of the endometrial stroma by the cancer. With progression of the disease, the myometrium is infiltrated.<ref name="Weidner's">{{cite book |author=Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor) |title=Modern Surgical Pathology (2 Volume Set) |publisher=W B Saunders |location=London |year= |pages= |isbn=0-7216-7253-1 |oclc= |doi=}}</ref> | The histopathology of endometrial cancers is highly diverse. The most common finding is a ''well-differentiated endometrioid adenocarcinoma'', which is composed of numerous, small, crowded glands with varying degrees of nuclear atypia, mitotic activity, and stratification. This often appears on a background of endometrial hyperplasia. Frank adenocarcinoma may be distinguished from atypical hyperplasia by the finding of clear stromal invasion, or "back-to-back" glands which represent nondestructive replacement of the endometrial stroma by the cancer. With progression of the disease, the myometrium is infiltrated.<ref name="Weidner's">{{cite book |author=Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor) |title=Modern Surgical Pathology (2 Volume Set) |publisher=W B Saunders |location=London |year= |pages= |isbn=0-7216-7253-1 |oclc= |doi=}}</ref>. There is a [[squamous]] component on histology. This component can either be [[benign]] (called [[adenocanthoma]]) or could be [[malignant]] ([[adenosquamous]]). It is important to find out the grade of adeno component in the histology section as it does affect prognosis. [[Secretory]] variety have best prognosis but is least common. [[Papillary]] [[serous]] and [[clear cell]] varieties are also less common with poorer prognosis. | ||
==References== | ==References== | ||
Revision as of 02:56, 23 September 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
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Microscopic pathology
The histopathology of endometrial cancers is highly diverse. The most common finding is a well-differentiated endometrioid adenocarcinoma, which is composed of numerous, small, crowded glands with varying degrees of nuclear atypia, mitotic activity, and stratification. This often appears on a background of endometrial hyperplasia. Frank adenocarcinoma may be distinguished from atypical hyperplasia by the finding of clear stromal invasion, or "back-to-back" glands which represent nondestructive replacement of the endometrial stroma by the cancer. With progression of the disease, the myometrium is infiltrated.[1]. There is a squamous component on histology. This component can either be benign (called adenocanthoma) or could be malignant (adenosquamous). It is important to find out the grade of adeno component in the histology section as it does affect prognosis. Secretory variety have best prognosis but is least common. Papillary serous and clear cell varieties are also less common with poorer prognosis.
References
- ↑ Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor). Modern Surgical Pathology (2 Volume Set). London: W B Saunders. ISBN 0-7216-7253-1.