Histoplasmosis: Difference between revisions

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==Symptoms==
==Symptoms==
[[Chest X-ray]] findings are normal in 40-70% of cases.<ref name=Silberberg_2007 /> Chronic histoplasmosis cases can  resemble [[tuberculosis]]; disseminated histoplasmosis affects multiple organ systems and is fatal unless treated.
Chronic histoplasmosis cases can  resemble [[tuberculosis]]; disseminated histoplasmosis affects multiple organ systems and is fatal unless treated.


While histoplasmosis is the most common cause of fibrosing [[mediastinitis]], this remains a relatively rare disease.  Severe infections can cause [[hepatosplenomegaly]], [[lymphadenopathy]], and adrenal enlargement.  Lesions have a tendency to ''calcify'' as they heal.
While histoplasmosis is the most common cause of fibrosing [[mediastinitis]], this remains a relatively rare disease.  Severe infections can cause [[hepatosplenomegaly]], [[lymphadenopathy]], and adrenal enlargement.  Lesions have a tendency to ''calcify'' as they heal.

Revision as of 15:28, 26 September 2012

Histoplasmosis
Histoplasma capsulatum. Methenamine silver stain showing histopathologic changes in histoplasmosis.
ICD-10 B39
ICD-9 115
DiseasesDB 5925
MedlinePlus 001082
MeSH D006660

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Ajellomyces capsulatus; Darling disease; Darling's disease

Overview

Pathogen

Symptoms

Chronic histoplasmosis cases can resemble tuberculosis; disseminated histoplasmosis affects multiple organ systems and is fatal unless treated.

While histoplasmosis is the most common cause of fibrosing mediastinitis, this remains a relatively rare disease. Severe infections can cause hepatosplenomegaly, lymphadenopathy, and adrenal enlargement. Lesions have a tendency to calcify as they heal.

Ocular histoplasmosis damages the retina of the eyes. Scar tissue is left on the retina which can experience leakage, resulting in a loss of vision not unlike macular degeneration.

Treatment

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References


Note: The original version of this article is adapted from the U.S. CDC public domain document at http://www.cdc.gov/ncidod/dbmd/diseaseinfo/histoplasmosis_g.htm

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