Minimal change disease: Difference between revisions

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Revision as of 14:47, 28 September 2012

Template:DiseaseDisorder infobox For patient information, click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Associate Editor-In-Chief:’’’ Cafer Zorkun, M.D., Ph.D. [2]

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Minimal change disease from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Treatment

Case Studies

Case #1

Template:Nephrology sv:Minimal change disease

Template:WikiDoc Sources

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-==Overview==
+==[[Minimal change disease overview|Overview]]==
-'''Minimal change disease''' or ''nil disease'' (lipoid nephrosis) is a disease of the [[kidney]] which causes [[nephrotic syndrome]] and usually affects children (peak incidence at 2-3 years of age).<ref name=Robbins_2005>{{cite book | author = Kumar V, Fausto N, Abbas A (editors) | title = Robbins & Cotran Pathologic Basis of Disease | edition = 7th | pages=pp. 981-2 | publisher = Saunders | year = 2003 | id = ISBN 978-0-721-60187-8 }}</ref>
+==[[Minimal change disease historical perspective|Historical Perspective]]==
-==Symptoms==
+==[[Minimal change disease classification|Classification]]==
-The symptoms are [[proteinuria]] (leakage of protein into the urine) and [[water retention]].  There are other kidney diseases that have these same symptoms but a [[needle biopsy]] shows change in the kidney tissue if these other diseases are present.
-==Causes==
+==[[Minimal change disease pathophysiology|Pathophysiology]]==
-Minimal change disease can be associated with food allergies, medications, or hematologic malignancies, or it can occur [[idiopathic|idiopathically]]. The pathology does not appear to involve complement, [[Antibody|immunoglobulins]], or immune complex deposition. Rather, an altered cell-mediated immunologic response with abnormal secretion of [[lymphokine]]s by [[T cell]]s is thought to reduce the production of anions in the [[glomerular basement membrane]], thereby increasing the glomerular permeability to [[serum albumin]] through a reduction of electrostatic repulsion.<ref name=Mathieson_2003>{{cite journal |author=Mathieson P |title=Immune dysregulation in minimal change nephropathy |journal=Nephrol Dial Transplant |volume=18 Suppl 6 |issue= |pages=vi26-9 |year=2003 |pmid=12953038}}</ref> The loss of [[Anion|anionic]] charges is also thought to favor foot process fusion.  With minimal change disease the kidney tissue appears normal under a light microscope, but shows [[podocyte]] foot process effacement under an [[Electron microscopy|electron microscope]].<ref name=Robbins_2005 />
-==Treatment==
+==[[Minimal change disease causes|Causes]]==
-[[Prednisone]] is prescribed along with a blood pressure medication, typically an [[ACE inhibitor]] such as [[lisinopril]].  Often the liver is overactive with minimal change disease and over produces [[cholesterol]].  Therefore a [[statin]] drug is often prescribed for the duration of the treatment.  When the urine is clear of protein, the drugs can be discontinued. 50% of patients will relapse and need further treatment.
+==[[Minimal change disease differential diagnosis|Differentiating Minimal change disease from other Diseases]]==
+==[[Minimal change disease epidemiology and demographics|Epidemiology and Demographics]]==
+==[[Minimal change disease risk factors|Risk Factors]]==
+==[[Minimal change disease screening|Screening]]==
+==[[Minimal change disease natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
-==Other notes==
+==Diagnosis==
-% of those who get minimal change disease have a recurrence with 20% never realizing another occurrence.  Some authors have noted that other conditions associated with T-cell abnormalities, such as [[Hodgkin's disease]] and [[T-cell lymphoma]], are sometimes associated with minimal change disease.
+[[Minimal change disease staging|Staging]] | [[Minimal change disease history and symptoms|History and Symptoms]] | [[Minimal change disease physical examination|Physical Examination]] | [[Minimal change disease laboratory findings|Laboratory Findings]] | [[Minimal change disease chest x ray|Chest X Ray]] | [[Minimal change disease CT|CT]] | [[Minimal change disease MRI|MRI]] | [[Minimal change disease other imaging findings|Other Imaging Findings]] | [[Minimal change disease other diagnostic studies|Other Diagnostic Studies]]
-==External links==
+==Treatment==
+[[Minimal change disease medical therapy|Medical Therapy]] | [[Minimal change disease surgery|Surgery]] | [[Minimal change disease primary prevention|Primary Prevention]] | [[Minimal change disease secondary prevention|Secondary Prevention]] | [[Minimal change disease cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] |  [[Minimal change disease future or investigational therapies|Future or Investigational Therapies]]
-* [http://www.kidcomm.org Kidcomm] - An online resource for parents dealing with childhood kidney diseases
+==Case Studies==
-* [http://www.kidney.org National Kidney Foundation]
-==References==
+[[Minimal change disease case study one|Case #1]]
-{{Reflist|2}}

Minimal change disease: Difference between revisions

Revision as of 14:47, 28 September 2012

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