Ankylosing spondylitis risk factors: Difference between revisions
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==Overview== | ==Overview== | ||
Patients with [[HLA-B27]] variant are at highest risk of developing ankylosing spondylitis. | |||
==Risk Factors== | ==Risk Factors== | ||
Variations of the HLA-B gene increase the risk of developing ankylosing spondylitis, although it is not a diagnostic test. Those with the [[HLA-B27]] variant are at highest risk of developing the disorder. HLA-B27, demonstrated in a [[blood test]], is occasionally used as a diagnostic, but does not distinguish AS from other diseases and is therefore not of real diagnostic value. Over 95% of people with AS are HLA-B27 positive, although this ratio varies from population to population (only 50% of African American patients with AS possess HLA-B27, and it is close to 80% among AS patients from Mediterranean countries). | Variations of the HLA-B gene increase the risk of developing ankylosing spondylitis, although it is not a diagnostic test. Those with the [[HLA-B27]] variant are at highest risk of developing the disorder. HLA-B27, demonstrated in a [[blood test]], is occasionally used as a diagnostic, but does not distinguish AS from other diseases and is therefore not of real diagnostic value. Over 95% of people with AS are HLA-B27 positive, although this ratio varies from population to population (only 50% of African American patients with AS possess HLA-B27, and it is close to 80% among AS patients from Mediterranean countries). | ||
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==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[Category:Arthritis]] | |||
[[Category:Autoimmune diseases]] | |||
Revision as of 14:49, 26 October 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Patients with HLA-B27 variant are at highest risk of developing ankylosing spondylitis.
Risk Factors
Variations of the HLA-B gene increase the risk of developing ankylosing spondylitis, although it is not a diagnostic test. Those with the HLA-B27 variant are at highest risk of developing the disorder. HLA-B27, demonstrated in a blood test, is occasionally used as a diagnostic, but does not distinguish AS from other diseases and is therefore not of real diagnostic value. Over 95% of people with AS are HLA-B27 positive, although this ratio varies from population to population (only 50% of African American patients with AS possess HLA-B27, and it is close to 80% among AS patients from Mediterranean countries).