Acute liver failure pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
== Pathophysiology== | == Pathophysiology== | ||
Acute liver failure is caused due to extensive damage to the liver tissue, causing severe compromise of its function. The effects of acute liver failure are due to loss of its metabolic, secretory and regulatory effects. This results in accumulation of toxic substances and causes deleterious effects. The major cause of morbidity and mortality in patients of liver failure is due to the development of cerebral edema which causes altered sensorium and increased intracranial pressure. | |||
==Pathology== | |||
In the majority of acute liver failure (ALF) there is widespread hepatocellular necrosis beginning in the [[hepatic lobule|centrizonal distribution]] and progressing towards portal tracts. The degree of [[parenchyma]]l inflammation is variable and is proportional to duration of [[disease]]<ref>{{cite journal |author=Boyer JL, Klatskin G |title=Pattern of necrosis in acute viral hepatitis. Prognostic value of bridging (subacute hepatic necrosis) |journal=N. Engl. J. Med. |volume=283 |issue=20 |pages=1063-71 |year=1970 |pmid=4319402 |doi=}}</ref>. | In the majority of acute liver failure (ALF) there is widespread hepatocellular necrosis beginning in the [[hepatic lobule|centrizonal distribution]] and progressing towards portal tracts. The degree of [[parenchyma]]l inflammation is variable and is proportional to duration of [[disease]]<ref>{{cite journal |author=Boyer JL, Klatskin G |title=Pattern of necrosis in acute viral hepatitis. Prognostic value of bridging (subacute hepatic necrosis) |journal=N. Engl. J. Med. |volume=283 |issue=20 |pages=1063-71 |year=1970 |pmid=4319402 |doi=}}</ref>. | ||
Revision as of 04:26, 27 October 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
Acute liver failure is caused due to extensive damage to the liver tissue, causing severe compromise of its function. The effects of acute liver failure are due to loss of its metabolic, secretory and regulatory effects. This results in accumulation of toxic substances and causes deleterious effects. The major cause of morbidity and mortality in patients of liver failure is due to the development of cerebral edema which causes altered sensorium and increased intracranial pressure.
Pathology
In the majority of acute liver failure (ALF) there is widespread hepatocellular necrosis beginning in the centrizonal distribution and progressing towards portal tracts. The degree of parenchymal inflammation is variable and is proportional to duration of disease[1].