Acute liver failure classification: Difference between revisions
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==Classification== | ==Classification== | ||
The 1993 classification defines <ref>O'Grady JG, Schalm SW, Williams R. Acute liver failure: redefining the syndromes. ''[[The Lancet|Lancet]] 1993;342:273-5. PMID 8101303.</ref> | The 1993 classification defines three subcategories based on the severity and duration of the acute liver failure. <ref>O'Grady JG, Schalm SW, Williams R. Acute liver failure: redefining the syndromes. ''[[The Lancet|Lancet]] 1993;342:273-5. PMID 8101303.</ref> The importance of this method of classification is that the pace of the disease evolution strongly influences prognosis. The underlying [[etiology]] causing the development of acute liver failure is the other significant determinant in regards to prognosis.<ref name="ogredy1">{{cite journal |author=O'Grady JG |title=Acute liver failure |journal=Postgraduate medical journal |volume=81 |issue=953 |pages=148-54 |year=2005 |pmid=15749789 |doi=10.1136/pgmj.2004.026005}}</ref> This classification system is based upon the duration between onset of [[jaundice]] to onset of [[encephalopathy]]. | ||
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Acute liver failure can be classified into fulminant or subfulminant. Both the forms have poor prognosis. It is based upon the duration between onset of hepatic illness to development of encephalopathy.<ref name="pmid9027947">{{cite journal |author=Williams R |title=Classification, etiology, and considerations of outcome in acute liver failure |journal=[[Seminars in Liver Disease]] |volume=16 |issue=4 |pages=343–8 |year=1996 |month=November |pmid=9027947 |doi=10.1055/s-2007-1007247 |url=http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-1007247 |accessdate=2012-10-26}}</ref> | Acute liver failure can also be classified into fulminant or subfulminant. Both the forms have poor prognosis. It is based upon the duration between onset of hepatic illness to development of encephalopathy.<ref name="pmid9027947">{{cite journal |author=Williams R |title=Classification, etiology, and considerations of outcome in acute liver failure |journal=[[Seminars in Liver Disease]] |volume=16 |issue=4 |pages=343–8 |year=1996 |month=November |pmid=9027947 |doi=10.1055/s-2007-1007247 |url=http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-1007247 |accessdate=2012-10-26}}</ref> | ||
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! Classification !! Time for Hepatic Encephalopathy | ! Classification !! Time for Hepatic Encephalopathy | ||
Revision as of 17:23, 28 October 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2]
Overview
Acute liver failure is classified into three subcategories; hyperacute , acute, and subacute depending upon the time lapsed between the appearance of jaundice, to the development of encephalopathy. In can also be classified into fulminant and subfulminant based upon the time that has lapsed from the start if illness to the onset of encephalopathy.
Classification
The 1993 classification defines three subcategories based on the severity and duration of the acute liver failure. [1] The importance of this method of classification is that the pace of the disease evolution strongly influences prognosis. The underlying etiology causing the development of acute liver failure is the other significant determinant in regards to prognosis.[2] This classification system is based upon the duration between onset of jaundice to onset of encephalopathy.
| Time | Classification |
|---|---|
| 1 week | Hyperacute |
| 1 week - 1 month | Acute |
| 1 week - 3 months | Subacute |
Acute liver failure can also be classified into fulminant or subfulminant. Both the forms have poor prognosis. It is based upon the duration between onset of hepatic illness to development of encephalopathy.[3]
| Classification | Time for Hepatic Encephalopathy |
|---|---|
| Fulminant | within 2 months |
| Subfulminant | within 2 months to 6 months |
References
- ↑ O'Grady JG, Schalm SW, Williams R. Acute liver failure: redefining the syndromes. Lancet 1993;342:273-5. PMID 8101303.
- ↑ O'Grady JG (2005). "Acute liver failure". Postgraduate medical journal. 81 (953): 148–54. doi:10.1136/pgmj.2004.026005. PMID 15749789.
- ↑ Williams R (1996). "Classification, etiology, and considerations of outcome in acute liver failure". Seminars in Liver Disease. 16 (4): 343–8. doi:10.1055/s-2007-1007247. PMID 9027947. Retrieved 2012-10-26. Unknown parameter
|month=ignored (help)