Shigellosis natural history, complications and prognosis: Difference between revisions
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*:* [[Thrombocytopenia]] | *:* [[Thrombocytopenia]] | ||
*:* [[Acute Renal Failure]]<ref>http://www.cdc.gov/ncidod/dbmd/diseaseinfo/shigellosis_t.htm </ref><ref>http://www.cdc.gov/ncidod/dbmd/diseaseinfo/shigellosis_g.htm </ref> | *:* [[Acute Renal Failure]]<ref>http://www.cdc.gov/ncidod/dbmd/diseaseinfo/shigellosis_t.htm </ref><ref>http://www.cdc.gov/ncidod/dbmd/diseaseinfo/shigellosis_g.htm </ref> | ||
About 1 in 10 children with severe shigella enteritis develop neurological problems including [[febrile seizures]] or brain disease ([[encephalopathy]]) with [[headache]], [[lethargy]], [[confusion]], and stiff neck. | |||
==Prognosis== | ==Prognosis== | ||
Revision as of 16:04, 21 November 2012
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Overview
Infections are associated mucosal ulceration, rectal bleeding, drastic dehydration; fatality may be as high as 10-15% with some strains. Reiter's disease, reactive arthritis, and hemolytic uremic syndrome are possible sequelae that have been reported in the aftermath of shigellosis.
Complications
Reiter's syndrome is a late complication of S. flexneri infection, especially in persons with the genetic marker HLA-B27. Hemolytic-uremic syndrome can occur after S. dysenteriae type 1 infection. Convulsions may occur in children; the mechanism may be related to a rapid rate of temperature elevation or metabolic alterations [1]
- Intestinal Complications (Rare)
- Systemic Complications
- Bacteremia (gram-negative rod's (GNR’s), not just Shigella)
- Hyponatremia (syndrome of inappropriate antidiuretic hormone secretion (SIADH)
- Leukemoid Reactions
- Seizure
- Reactive Arthritis
- Hemolytic Uremic Syndrome
About 1 in 10 children with severe shigella enteritis develop neurological problems including febrile seizures or brain disease (encephalopathy) with headache, lethargy, confusion, and stiff neck.
Prognosis
Often the infection is mild and goes away on its own. Most patients, except malnourished children and those with weakened immune systems, have an excellent outlook.