Amyotrophic lateral sclerosis: Difference between revisions

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==Diagnosis==
==Diagnosis==
[[Amyotrophic lateral sclerosis history and symptoms|History and Symptoms]] | [[Amyotrophic lateral sclerosis physical examination|Physical Examination]] | [[Amyotrophic lateral sclerosis laboratory findings|Laboratory Findings]]
[[Amyotrophic lateral sclerosis diagnostic evaluation|Diagnostic Evaluation]] | [[Amyotrophic lateral sclerosis history and symptoms|History and Symptoms]] | [[Amyotrophic lateral sclerosis physical examination|Physical Examination]] | [[Amyotrophic lateral sclerosis laboratory findings|Laboratory Findings]]
 
 


==Etiology==
==Etiology==

Revision as of 17:05, 27 November 2012

Amyotrophic lateral sclerosis
Stephen Hawking, a physicist who has ALS.
ICD-10 G12.2
ICD-9 335.20
OMIM 105400
DiseasesDB 29148
MedlinePlus 000688
MeSH D000690

Amyotrophic lateral sclerosis Microchapters

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Epidemiology and Demographics

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Diagnostic Study of Choice

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: ALS; Lou-Gehrig's disease; maladie de Charcot; upper and lower motor neuron disease; motor neuron disease


Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Amyotrophic lateral sclerosis from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Evaluation | History and Symptoms | Physical Examination | Laboratory Findings

Etiology

Prognosis

Regardless of the part of the body first affected by the disease, it is usual for muscle weakness and atrophy to spread to other parts of the body as the disease progresses. It is important to remember that some patients with ALS have an arrested course with no progression beyond a certain point despite extensive follow-up. Such a pattern is particularly true for young males with predominant upper limb weakness especially on one side (so-called monomelic or Hirayama type mother neuron disease). Eventually people with ALS will not be able to stand or walk, get in or out of bed on their own, or use their hands and arms. In later stages of the disease, individuals have difficulty breathing as the muscles of the respiratory system weaken. Although ventilation support can ease problems with breathing and prolong survival, it does not affect the progression of ALS. Most people with ALS die from respiratory failure, usually within 3 to 5 years from the onset of symptoms. However, about 10 percent of those individuals with ALS survive for 10 or more years.

Resources

United States

International

United Kingdom

Canada

Australia

  • Motor Neurone Disease Association of Australia [3]

Awareness and fundraising events

  • The Ride For Life, founded in 1998 by ALS patient and former teacher Chris Pendergast. Chris and other ALS patients made a wheelchair ride from Yankee Stadium to Washington D.C.—a 350-mile journey. The ride continues annually and, in recent years, has centered on the New York Metro area. Their mission is to raise public awareness of ALS, help fund research, support ALS patients and their families, and provide the ALS community with the latest ALS related news, information and inspiration. Since 1998, Ride for Life has earned nearly 3 million dollars for ALS research and patient services.
  • Augie's Quest [4] was started by fitness pioneer Augie Nieto in cooperation with the Muscular Dystrophy Association after his diagnosis with the disease. Augie's Quest and ALS TDI entered into the largest private funding collaboration in the history of the disease, $36 million, in 2006. All funds raised through Augie's Quest events go 100% to ALS research.
  • The Walk to D'Feet ALS held annually by the ALS Association, where walkers raise awareness and money to fight and cure ALS.
  • Prize 4 Life, a group of recent Harvard Business School graduates founded Prize4Life, a nonprofit to turbo charge ALS research because one or their classmates, Avi Kremer, MBA 2007 and Chairman of Prize4Life, was diagnosed with this fatal illness in the fall of 2004. Prize4Life is a results-oriented nonprofit founded to accelerate ALS/MND research by offering substantial prizes to scientists who solve the most critical scientific problems preventing the discovery of an effective ALS/MND treatment. The Prize4Life concept is inspired by other prize awards for stimulating research, such as the X-Prize for commercial space travel and DNA-decoding, the U.S. government’s H-Prize for hydrogen renewable energy, and Eli Lilly’s venture, InnoCentive, which outsources difficult R&D problems to a distributed network of scientists using prizes.

See also

External links

References

General Muscular Dystrophy

This article incorporates in public domain text from The U.S. National Institute of Neurological Disorders and Stroke

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