Aortic stenosis risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editors-In-Chief: Mohammed A. Sbeih, M.D. [2]; Assistant Editor-In-Chief: Kristin Feeney, B.S. [3]

Overview

The most common risk factor for the development of aortic stenosis is the presence of a congenital bicuspid aortic valve.

Risk Factors

• Common risk factors for the development of aortic stenosis include:

• Age-related progressive calcification of the normal tricuspid aortic valve ( >50% of cases).
• Congenital bicuspid aortic valve that may subsequently become calcified later in life (30-40% of cases).
• Acute rheumatic fever (< 10% of cases).

• Other risk factors that may speed up the progression of aortic stenosis include the same risk factors as atherosclerosis:

• Hypertension
• Diabetes mellitus
• Hyperlipoproteinemia
• Uremia
• Smoking

• Radiation therapy or treatment of cancer, such as breast cancer or lymphoma, may also increase the risk of aortic stenosis.