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| __NOTOC__ | | __NOTOC__ |
| {{Kaposi's sarcoma}} | | {{Kaposi's sarcoma}} |
| {{CMG}}
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| Please help WikiDoc by adding more content here. It's easy! Click [[Help:How_to_Edit_a_Page|here]] to learn about editing.
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| ==Overview==
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| ==Epidemiological Varieties==
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| '''Classic KS'''
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| As originally described was a relatively indolent disease affecting elderly men from the Mediterranean region, or of Eastern European Jewish descent.<ref>{{cite journal |last=Iscovich |first=J |authorlink= |coauthors= |year=1998 |month=Oct 22|title=Classic Kaposi's sarcoma in Jews living in Israel, 1961-1989: a population-based incidence study. |journal=AIDS |volume=12 |issue=15 |pages=2067-72 |id= |url=http://www.aidsonline.com/pt/re/aids/abstract.00002030-199815000-00019.htm;jsessionid=Gy0NY0Y2b5lXKwJTGkQv1C1SdhTymxKmhpM4Hkrdvvz3pyXQ9GPV!-1804036389!-949856145!8091!-1 |accessdate= |quote= }}</ref><ref>{{cite journal |last=Fenig |first=E |authorlink= |coauthors= |year=1998 |month=Oct |title=Classic Kaposi sarcoma: experience at Rabin Medical Center in Israel. |journal=Am J Clin Oncol |volume=21 |issue=5 |pages=498-500 |id= |url=http://www.amjclinicaloncology.com/pt/re/ajco/abstract.00000421-199810000-00016.htm;jsessionid=Gy0Jys29KWqzWg4RWhQN9vCyvP3tMPn24WG35BQbdLHGlhJc1y7S!-1804036389!-949856145!8091!-1 |accessdate= |quote= }}</ref>
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| '''Endemic KS'''
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| Was described later in young African people, mainly from sub-Saharan Africa, as a more aggressive disease which infiltrated the skin extensively, especially on the lower limbs. This, it should be noted, is unrelated to [[HIV]] infection.<ref>{{cite journal |last=Cook-Mozaffari |first=P |authorlink= |coauthors= |year=1998 |month=Dec |title=The geographical distribution of Kaposi's sarcoma and of lymphomas in Africa before the AIDS epidemic |journal=Br J Cancer |volume=78 |issue=11 |pages=1521-8 |id= |url=http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=9836488&dopt=Citation |accessdate= |quote= }}</ref><ref>{{cite journal |last=Olsen |first=SJ |authorlink= |coauthors= |year=1998 |month=Oct |title=Increasing Kaposi's sarcoma-associated herpesvirus seroprevalence with age in a highly Kaposi's sarcoma endemic region, Zambia in 1985. |journal=AIDS |volume=12 |issue=14 |pages=1921-5 |id= |url=http://dceg.cancer.gov/pdfs/olsen1219211998.pdf |accessdate= |quote= }}</ref>
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| '''Transplant Related KS'''
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| Had been described, but only rarely until the advent of [[Immunosuppressive drug#Drugs acting on immunophilins|calcineurin inhibitors]] (such as [[ciclosporin]], which are inhibitors of [[T-cell]] function) for [[transplant]] patients in the 1980s, when its incidence grew rapidly.<ref>{{cite journal |last=Qunibi |first=W |authorlink= |coauthors= |year=1998 |month=Feb 27 |title=Serologic association of human herpesvirus eight with posttransplant Kaposi's sarcoma in Saudi Arabia |journal=Transplantation |volume=65 |issue=4 |pages=583-5 |id= |url=http://www.transplantjournal.com/pt/re/transplantation/abstract.00007890-199802270-00024.htm;jsessionid=Gy4Gq82dl1t9ppllm80G1PDjkbpmqFFkp2ypLSLnW2DthLg22DcM!220059229!-949856144!8091!-1 |accessdate= |quote= }}</ref><ref>{{cite journal |last= Luppi |first=Mario |authorlink= |coauthors= |year=2000 |month=Nov 9 |title=Bone marrow failure associated with human herpesvirus 8 infection after transplantation |journal=N Engl J Med |volume=343 |issue=19 |pages=1378-85 |id= |url=http://content.nejm.org/cgi/content/abstract/343/19/1378 |accessdate= |quote= }}</ref>
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| '''Epidemic KS'''
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| Was described during the 1980s as an aggressive disease in [[AIDS]] patients (HIV also causes a defect in T-cell immunity). It is over 300 times more common in AIDS patients than in renal transplant recipients. <ref>{{cite journal |last=Beral |first=V |authorlink= |coauthors= |year=1990 |month=Jan 20 |title=Kaposi's sarcoma among persons with AIDS: a sexually transmitted infection? |journal=Lancet |volume=335 |issue=8682 |pages=123-8 |id= |url=http://www.ncbi.nlm.nih.gov/sites/entrez?db=PubMed&cmd=Retrieve&list_uids=1967430&dopt=Citation |accessdate= |quote= }}</ref>
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| Note that HHV-8 is responsible for all varieties of KS.
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| ==Demographics==
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| ==References== | | ==References== |
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| {{Reflist|2}} | | {{Reflist|2}} |
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| [[Category:Needs content]] | | [[Category:Needs content]] |
| [[Category:Disease]] | | [[Category:Disease]] |
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| [[Category:Infectious disease]] | | [[Category:Infectious disease]] |
| [[Category:Mature chapter]] | | [[Category:Mature chapter]] |
| | {{WH}} |
| | {{WS}} |