Atypical teratoid rhabdoid tumor laboratory findings: Difference between revisions
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==Immunohistochemistry== | ==Immunohistochemistry== | ||
[[Immunohistochemistry]] refers to the process of localizing proteins in cells of a tissue section exploiting the principle of antibodies binding specifically to antigens in biological tissues. A tissue sample is stained to identify specific cellular proteins. Immunohistochemical staining is widely used in the diagnosis and treatment of cancer. Specific molecular markers are characteristic of particular cancer types. Immunohistochemistry is also widely used in basic research to understand the distribution and localization of biomarkers in different parts of a tissue. Below are proteins found in an | [[Immunohistochemistry]] refers to the process of localizing proteins in cells of a tissue section exploiting the principle of antibodies binding specifically to antigens in biological tissues. A tissue sample is stained to identify specific cellular proteins. Immunohistochemical staining is widely used in the diagnosis and treatment of cancer. Specific molecular markers are characteristic of particular cancer types. Immunohistochemistry is also widely used in basic research to understand the distribution and localization of biomarkers in different parts of a tissue. Below are proteins found in an atypical teratoid rhabdoid tumor. | ||
*[[Vimentin]]-positive | *[[Vimentin]]-positive | ||
Revision as of 19:48, 29 November 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Laboratory Findings
Examination of the cerebrospinal fluid is important as one-third of patients will have intracranial dissemination with involvement of the cerebrospinal fluid (CSF). Large tumor cells, eccentricity of the nuclei and prominent nucleoli are consistent findings.[1]
Immunohistochemistry
Immunohistochemistry refers to the process of localizing proteins in cells of a tissue section exploiting the principle of antibodies binding specifically to antigens in biological tissues. A tissue sample is stained to identify specific cellular proteins. Immunohistochemical staining is widely used in the diagnosis and treatment of cancer. Specific molecular markers are characteristic of particular cancer types. Immunohistochemistry is also widely used in basic research to understand the distribution and localization of biomarkers in different parts of a tissue. Below are proteins found in an atypical teratoid rhabdoid tumor.
- Vimentin-positive
- Cytokeratin-positive
- Neuron specific enolase-positive
- Epitelial membrane antigen-positive
- Glial fibrillary acidic protein- positive
- Synaptophysin
- Chromogranin
- Smooth muscle actin
- Desmin
- Carcinoembrionary antigen
- CD99
- S-100
- neurofilaments
- AFP- not found
- HCG – negative