Central pontine myelinolysis pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
Rapid correction of [[hypernatremia]] causes water to move into cells, leading to multiple cerebral hemorrhages, equally catastrophic as osmotic demyelination. | |||
==Pathophysiology== | ==Pathophysiology== | ||
Brain cells adjust their osmolarities by changing levels of certain [[osmolytes]] like [[Inositol]], [[Betaine]], and [[Glutamine]]. In [[hyponatremia]] the levels of these osmolytes fall, preventing entry of free-water into cells. The reverse is true for [[hypernatremia]]. So rapid correction of [[sodium]] in [[hyponatremia]] would cause the extra cellular fluid to be relatively hypertonic. Free-water would then move out of the cells. This leads to central pontine myelinolysis. Rapid correction of [[hypernatremia]] causes water to move into cells, leading to multiple cerebral hemorrhages, equally catastrophic as osmotic demyelination. | Brain cells adjust their osmolarities by changing levels of certain [[osmolytes]] like [[Inositol]], [[Betaine]], and [[Glutamine]]. In [[hyponatremia]] the levels of these osmolytes fall, preventing entry of free-water into cells. The reverse is true for [[hypernatremia]]. So rapid correction of [[sodium]] in [[hyponatremia]] would cause the extra cellular fluid to be relatively hypertonic. Free-water would then move out of the cells. This leads to central pontine myelinolysis. Rapid correction of [[hypernatremia]] causes water to move into cells, leading to multiple cerebral hemorrhages, equally catastrophic as osmotic demyelination. | ||
Revision as of 20:45, 3 December 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Rapid correction of hypernatremia causes water to move into cells, leading to multiple cerebral hemorrhages, equally catastrophic as osmotic demyelination.
Pathophysiology
Brain cells adjust their osmolarities by changing levels of certain osmolytes like Inositol, Betaine, and Glutamine. In hyponatremia the levels of these osmolytes fall, preventing entry of free-water into cells. The reverse is true for hypernatremia. So rapid correction of sodium in hyponatremia would cause the extra cellular fluid to be relatively hypertonic. Free-water would then move out of the cells. This leads to central pontine myelinolysis. Rapid correction of hypernatremia causes water to move into cells, leading to multiple cerebral hemorrhages, equally catastrophic as osmotic demyelination.