Microsporidiosis secondary prevention: Difference between revisions
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===Prevention of Recurrence=== | ===Prevention of Recurrence=== | ||
Treatment for ocular microsporidiosis should be continued indefinitely because recurrence or [[relapse]] might follow treatment discontinuation ('''BIII'''). Whether treatment can be safely discontinued after immune restoration with [[ART]] is unknown, although it is reasonable, on the basis of the experience with discontinuation of secondary prophylaxis (chronic maintenance therapy) for other opportunistic infections during advanced HIV-1 disease, to discontinue chronic maintenance therapy if patients remain asymptomatic with regard to signs and symptoms of microsporidiosis and have a sustained (e.g. >6 months) increase in their [[CD4+ T lymphocyte]] counts to levels >200 cells/µL after [[ART]] ('''CIII'''). | Treatment for ocular microsporidiosis should be continued indefinitely because recurrence or [[relapse]] might follow treatment discontinuation ('''BIII'''). Whether treatment can be safely discontinued after immune restoration with [[ART]] is unknown, although it is reasonable, on the basis of the experience with discontinuation of secondary prophylaxis (chronic maintenance therapy) for other opportunistic infections during advanced HIV-1 disease, to discontinue chronic maintenance therapy if patients remain asymptomatic with regard to signs and symptoms of microsporidiosis and have a sustained (e.g. >6 months) increase in their [[CD4+ T lymphocyte]] counts to levels >200 cells/µL after [[ART]] ('''CIII'''). | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Secondary Prevention
Prevention of Recurrence
Treatment for ocular microsporidiosis should be continued indefinitely because recurrence or relapse might follow treatment discontinuation (BIII). Whether treatment can be safely discontinued after immune restoration with ART is unknown, although it is reasonable, on the basis of the experience with discontinuation of secondary prophylaxis (chronic maintenance therapy) for other opportunistic infections during advanced HIV-1 disease, to discontinue chronic maintenance therapy if patients remain asymptomatic with regard to signs and symptoms of microsporidiosis and have a sustained (e.g. >6 months) increase in their CD4+ T lymphocyte counts to levels >200 cells/µL after ART (CIII).