Ebola history and symptoms: Difference between revisions

Jump to navigation Jump to search
Kalsang Dolma (talk | contribs)
Kalsang Dolma (talk | contribs)
Line 27: Line 27:
*[[Purpura]]
*[[Purpura]]


Other secondary symptoms include:
*[[Hypotension]] (less than 90 mm Hg systolic /60 mm Hg diastolic)
*[[Hypovolemia]]
*[[Tachycardia]]
*Organ damage especially the:
**[[kidneys]]
**[[Spleen]]
**[[liver]]
**as a result of disseminated systemic [[necrosis]], and [[proteinuria]].
The interior bleeding is caused by a chemical reaction between the virus and the platelets which creates a chemical that will cut cell sized holes into the capillary walls. After 5-7 days the person will die of "a million cuts."
The interior bleeding is caused by a chemical reaction between the virus and the platelets which creates a chemical that will cut cell sized holes into the capillary walls. After 5-7 days the person will die of "a million cuts."
Occasionally, [[internal bleeding|internal]] and external hemorrhage from [[orifice]]s, such as the nose and mouth may also occur, as well as from incompletely healed injuries such as needle-puncture sites. Ebola virus can affect the levels of [[white blood cells]] and [[platelets]], disrupting [[thrombosis|clotting]]. Fewer than 50 percent of patients will not develop any hemorrhaging.
Occasionally, [[internal bleeding|internal]] and external hemorrhage from [[orifice]]s, such as the nose and mouth may also occur, as well as from incompletely healed injuries such as needle-puncture sites. Ebola virus can affect the levels of [[white blood cells]] and [[platelets]], disrupting [[thrombosis|clotting]]. Fewer than 50 percent of patients will not develop any hemorrhaging.
Methods of diagnosis of Ebola include testing saliva and urine samples. The span of time from onset of symptoms to death is usually between 7 and 14 days. By the second week of infection, patients will either [[defervescence|defervesce]] (the fever will lessen) or undergo systemic multi-organ failure. Mortality rates are generally high, ranging from 50% - 90%. The cause of death is usually due to [[Hypovolemia|hypovolemic shock]] or [[multiple organ dysfunction syndrome|organ failure]].<ref>{{cite journal |last=Bray |first=Mike |authorlink= |coauthors=Geisbert, Thomas W |year=2005 |month= |title=Ebola virus: The role of macrophages and dendritic cells in the pathogenesis of Ebola hemorrhagic fever |journal=International Journal of Biochemistry & Cell Biology |volume=37 |issue=8 |pages=1560-1566 |doi=10.1016/j.biocel.2005.02.018 |url= |accessdate= |quote= }}</ref> 
Filoviruses replicate well in a wide range of organs and cell types such as hepatocytes, epithelial cells, fibroblasts, fibroblastic reticular cells and adrenal cortical cells.<ref name="Klenk2004" />  Most notably, the susceptibility of human [[endothelial cells]] is likely the cause of the symptoms that appear in the late stages of the infection such as shock syndrome and hemorrhaging.<ref name="Klenk2004" />


==References==
==References==

Revision as of 18:03, 14 December 2012

Ebola Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Ebola from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Algorithm for the Evaluation of the Returned Traveler

Emergency Department Evaluation

Case Definition

History and Symptoms

Physical Examination

Laboratory Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Hospital Preparedness

Checklists

Air Medical Transport

Monitoring and Movement Following Exposure

Primary Prevention

Future or Investigational Therapies

Postmortem Care

Postmortem Care

Case Studies

Case #1

Ebola history and symptoms On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Ebola history and symptoms

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Ebola history and symptoms

CDC on Ebola history and symptoms

Ebola history and symptoms in the news

Blogs on Ebola history and symptoms

Directions to Hospitals Treating ebola

Risk calculators and risk factors for Ebola history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

History and Symptoms

1976 photograph of two nurses standing in front of Kinshasa case #3 (Nurse Mayinga) who was treated and later died in Ngaliema Hospital, in Kinshasa, Zaïre

Symptoms are varied and often appear suddenly. Initial symptoms include high:

Ebola may progress to cause more serious symptoms, such as:

The interior bleeding is caused by a chemical reaction between the virus and the platelets which creates a chemical that will cut cell sized holes into the capillary walls. After 5-7 days the person will die of "a million cuts." Occasionally, internal and external hemorrhage from orifices, such as the nose and mouth may also occur, as well as from incompletely healed injuries such as needle-puncture sites. Ebola virus can affect the levels of white blood cells and platelets, disrupting clotting. Fewer than 50 percent of patients will not develop any hemorrhaging.

References

Template:WH Template:WS