Congenital rubella syndrome pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
Congenital rubella syndrome results from the spread of infection to fetus by mother during viremic stage. Rubella virus enters fetus through the placenta and cause damage to all germ layers of fetus. This results in rapid death of some cells. | [[Congenital rubella syndrome]] results from the spread of infection to [[fetus]] by mother during viremic stage. Rubella virus enters fetus through the [[placenta]] and cause damage to all germ layers of fetus. This results in rapid death of some cells. | ||
==Pathophysiology== | ==Pathophysiology== | ||
Congenital rubella syndrome results from the infection of fetus by transmission of virus from the mother during the viremic stage of the infection. Virus travels through the blood stream of the fetus and damages the blood vessels. This results in ischemic injury to the cells in the germ layers. The risk of congenital infection and defects is highest during the first 12 weeks of gestation and decreases after the 12th week of gestation with defects rare after the 20th week of gestation. If infection occurs 0–28 days before conception, there is a 43% chance the infant will be affected. If the infection occurs 0–12 weeks after conception, there is a 51% chance the infant will be affected. If the infection occurs 13–26 weeks after conception there is a 23% chance the infant will be affected by the disease. Infants are not generally affected if rubella is contracted during the third trimester, or 26–40 weeks after conception. Problems rarely occur when rubella is contracted by the mother after 20 weeks of [[gestation]] and continues to disseminate the virus after birth. | [[Congenital rubella syndrome]] results from the [[infection]] of fetus by [[transmission]] of virus from the mother during the viremic stage of the infection. Virus travels through the blood stream of the fetus and damages the blood vessels. This results in ischemic injury to the cells in the germ layers. The risk of congenital infection and defects is highest during the first 12 weeks of gestation and decreases after the 12th week of [[gestation]] with defects rare after the 20th week of gestation. If infection occurs 0–28 days before [[conception]], there is a 43% chance the infant will be affected. If the infection occurs 0–12 weeks after conception, there is a 51% chance the infant will be affected. If the infection occurs 13–26 weeks after conception there is a 23% chance the infant will be affected by the disease. Infants are not generally affected if [[rubella]] is contracted during the third trimester, or 26–40 weeks after conception. Problems rarely occur when rubella is contracted by the mother after 20 weeks of [[gestation]] and continues to disseminate the virus after birth. | ||
==References== | ==References== | ||
Revision as of 18:48, 19 December 2012
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: : Kalsang Dolma, M.B.B.S.[2]
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Congenital Rubella Syndrome Microchapters |
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Differentiating Congenital Rubella Syndrome from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Congenital rubella syndrome pathophysiology On the Web |
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American Roentgen Ray Society Images of Congenital rubella syndrome pathophysiology |
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Directions to Hospitals Treating Congenital rubella syndrome |
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Risk calculators and risk factors for Congenital rubella syndrome pathophysiology |
Overview
Congenital rubella syndrome results from the spread of infection to fetus by mother during viremic stage. Rubella virus enters fetus through the placenta and cause damage to all germ layers of fetus. This results in rapid death of some cells.
Pathophysiology
Congenital rubella syndrome results from the infection of fetus by transmission of virus from the mother during the viremic stage of the infection. Virus travels through the blood stream of the fetus and damages the blood vessels. This results in ischemic injury to the cells in the germ layers. The risk of congenital infection and defects is highest during the first 12 weeks of gestation and decreases after the 12th week of gestation with defects rare after the 20th week of gestation. If infection occurs 0–28 days before conception, there is a 43% chance the infant will be affected. If the infection occurs 0–12 weeks after conception, there is a 51% chance the infant will be affected. If the infection occurs 13–26 weeks after conception there is a 23% chance the infant will be affected by the disease. Infants are not generally affected if rubella is contracted during the third trimester, or 26–40 weeks after conception. Problems rarely occur when rubella is contracted by the mother after 20 weeks of gestation and continues to disseminate the virus after birth.