Congenital rubella syndrome CDC case definitions: Difference between revisions
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An infant who does not meet the criteria for a probable or confirmed case but who has one or more of the following findings: | An infant who does not meet the criteria for a probable or confirmed case but who has one or more of the following findings: | ||
*[[Cataract]]s | *[[Cataract]]s | ||
* | *Congenital [[glaucoma]] | ||
*[[Congenital heart disease]] (most commonly [[patent ductus arteriosus]] or peripheral [[pulmonary artery stenosis]]) | *[[Congenital heart disease]] (most commonly [[patent ductus arteriosus]] or peripheral [[pulmonary artery stenosis]]) | ||
*[[Hearing impairment]] | *[[Hearing impairment]] | ||
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===Probable=== | ===Probable=== | ||
An infant who does not have laboratory confirmation of rubella infection but has at least two of the following, without a more plausible etiology: | An infant who does not have laboratory confirmation of rubella infection but has at least two of the following, without a more plausible etiology: | ||
*[[ | *[[Cataract]]s or congenital [[glaucoma]], | ||
*[[Congenital heart disease]] (most commonly patent ductus arteriosus or peripheral pulmonary artery stenosis), | *[[Congenital heart disease]] (most commonly patent ductus arteriosus or peripheral pulmonary artery stenosis), | ||
*[[Hearing impairment]] | *[[Hearing impairment]] | ||
| Line 42: | Line 42: | ||
An infant with at least one of the symptoms clinically consistent with congenital rubella syndrome listed above; and laboratory evidence of congenital rubella infection demonstrated by: | An infant with at least one of the symptoms clinically consistent with congenital rubella syndrome listed above; and laboratory evidence of congenital rubella infection demonstrated by: | ||
*Isolation of rubella | *Isolation of rubella virus or detection of rubella-specific immunoglogulin M ([[IgM]]) antibody, or infant rubella antibody level that persists at a higher level and for a longer period of time than expected from passive transfer of maternal antibody (i.e., rubella titer that does not drop at the expected rate of a two-fold decline per month), or a specimen that is PCR-positive for rubella virus. | ||
infant rubella antibody level that persists at a higher level and for a longer period of time than expected from passive transfer of maternal antibody (i.e., rubella titer that does not drop at the expected rate of a two-fold decline per month), or | |||
a specimen that is PCR-positive for rubella virus. | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 19:41, 19 December 2012
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Kalsang Dolma, M.B.B.S.[2]
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CDC Case Definations
Suspected
An infant who does not meet the criteria for a probable or confirmed case but who has one or more of the following findings:
- Cataracts
- Congenital glaucoma
- Congenital heart disease (most commonly patent ductus arteriosus or peripheral pulmonary artery stenosis)
- Hearing impairment
- Pigmentary retinopathy
- Purpura
- Hepatosplenomegaly
- Jaundice
- Microcephaly
- Developmental delay
- Meningoencephalitis or
- Radiolucent bone disease
Probable
An infant who does not have laboratory confirmation of rubella infection but has at least two of the following, without a more plausible etiology:
- Cataracts or congenital glaucoma,
- Congenital heart disease (most commonly patent ductus arteriosus or peripheral pulmonary artery stenosis),
- Hearing impairment
- Pigmentary retinopathy
OR
An infant who does not have laboratory confirmation of rubella infection but has at least one or more of the following, without a more plausible etiology:
- Cataracts or congenital glaucoma,
- Congenital heart disease (most commonly patent ductus arteriosus or peripheral pulmonary artery stenosis),
- Hearing impairment or
- Pigmentary retinopathy
AND one or more of the following:
- Purpura
- Hepatosplenomegaly
- Microcephaly
- Developmental delay
- Meningoencephalitis or
- Radiolucent bone disease
Confirmed
An infant with at least one of the symptoms clinically consistent with congenital rubella syndrome listed above; and laboratory evidence of congenital rubella infection demonstrated by:
- Isolation of rubella virus or detection of rubella-specific immunoglogulin M (IgM) antibody, or infant rubella antibody level that persists at a higher level and for a longer period of time than expected from passive transfer of maternal antibody (i.e., rubella titer that does not drop at the expected rate of a two-fold decline per month), or a specimen that is PCR-positive for rubella virus.