Lactic acidosis overview: Difference between revisions
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==Overview== | |||
Lactic acidosis is a condition caused by the buildup of [[lactic acid]] in the body. It leads to acidification of the blood ([[acidosis]]), and is considered a distinct form of [[metabolic acidosis]]. | |||
The cells produce lactic acid when they use [[glucose]] for energy in the absence of adequate [[oxygen]]. If too much lactic acid stays in the body, the balance tips and the person begins to feel ill. The signs of lactic acidosis are deep and rapid breathing, vomiting, and abdominal pain. Lactic acidosis may be caused by [[diabetic ketoacidosis]] or [[liver]] or [[kidney]] disease, as well as some forms of medication (most notably the anti-diabetic drug [[metformin]]). Some anti-HIV drugs ([[antiretroviral]]s) warn doctors in their prescribing information to regularly watch for symptoms of lactic acidosis caused by [[mitochondrial toxicity]]. | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Electrolyte disturbance]] | [[Category:Electrolyte disturbance]] | ||
[[Category:Medical emergencies]] | [[Category:Medical emergencies]] | ||
Revision as of 19:46, 12 February 2013
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Lactic acidosis is a condition caused by the buildup of lactic acid in the body. It leads to acidification of the blood (acidosis), and is considered a distinct form of metabolic acidosis.
The cells produce lactic acid when they use glucose for energy in the absence of adequate oxygen. If too much lactic acid stays in the body, the balance tips and the person begins to feel ill. The signs of lactic acidosis are deep and rapid breathing, vomiting, and abdominal pain. Lactic acidosis may be caused by diabetic ketoacidosis or liver or kidney disease, as well as some forms of medication (most notably the anti-diabetic drug metformin). Some anti-HIV drugs (antiretrovirals) warn doctors in their prescribing information to regularly watch for symptoms of lactic acidosis caused by mitochondrial toxicity.