Thrombosis causes: Difference between revisions
No edit summary |
(→Causes) |
||
| Line 6: | Line 6: | ||
[[Rudolf Virchow]] noted several factors affecting the clot formation, which are as follows: | [[Rudolf Virchow]] noted several factors affecting the clot formation, which are as follows: | ||
1) Alterations in blood flow ([[stasis]]) : Blood flows throughout the circulatory system, without significantly stopping or slowing any where. In certain pathological conditions where the blood flow slows down or stops, it causes | |||
*a) Increase in platelet to endothelium contact | *a) Increase in platelet to endothelium contact | ||
*b) Decrease the dilution of clotting factors | *b) Decrease the dilution of clotting factors | ||
This increases the risk of clot formation and form microthrombi, which further grow and propagate. | This increases the risk of clot formation and form microthrombi, which further grow and propagate. | ||
2) Injury to the vascular endothelium : Intrinsic or secondary to external trauma (Eg. catheterization) can cause [[Tunica intima|intimal]] damage and stimulates clot formation. See [[Coagulation]] | |||
3) Alterations in the constitution of blood ([[hypercoagulability]]) :It is the propensity to develop thrombosis due to an abnormality in the system of coagulation. | |||
These three conditions are collectively known as [[Virchow's triad]] and lead to intravascular [[coagulation]], forming a mass of [[red blood cell]]s, [[leukocyte]]s, and [[fibrin]]. | These three conditions are collectively known as [[Virchow's triad]] and lead to intravascular [[coagulation]], forming a mass of [[red blood cell]]s, [[leukocyte]]s, and [[fibrin]]. | ||
'''This video explains the process of thrombosis''' | '''This video explains the process of thrombosis:''' | ||
{{#ev:youtube|X_POCRsy7i4}} | {{#ev:youtube|X_POCRsy7i4}} | ||
Revision as of 15:42, 27 February 2013
|
Thrombosis Microchapters |
|
Site of Thrombosis |
|---|
|
Differentiating Thrombosis from other Diseases |
|
Diagnosis |
|
Treatment |
|
Thrombosis causes On the Web |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editors-in-Chief: Ujjwal Rastogi, MBBS [2]
Causes
Rudolf Virchow noted several factors affecting the clot formation, which are as follows:
1) Alterations in blood flow (stasis) : Blood flows throughout the circulatory system, without significantly stopping or slowing any where. In certain pathological conditions where the blood flow slows down or stops, it causes
- a) Increase in platelet to endothelium contact
- b) Decrease the dilution of clotting factors
This increases the risk of clot formation and form microthrombi, which further grow and propagate.
2) Injury to the vascular endothelium : Intrinsic or secondary to external trauma (Eg. catheterization) can cause intimal damage and stimulates clot formation. See Coagulation
3) Alterations in the constitution of blood (hypercoagulability) :It is the propensity to develop thrombosis due to an abnormality in the system of coagulation.
These three conditions are collectively known as Virchow's triad and lead to intravascular coagulation, forming a mass of red blood cells, leukocytes, and fibrin.
This video explains the process of thrombosis:
{{#ev:youtube|X_POCRsy7i4}}
Other Causes
High altitude [1], has also been known to induce thrombosis Occasionally, abnormalities in coagulation are to blame.
References
- ↑ Kuipers S, Cannegieter SC, Middeldorp S, Robyn L, Büller HR, Rosendaal FR (2007). "The absolute risk of venous thrombosis after air travel: a cohort study of 8,755 employees of international organisations". PLoS Med. 4 (9): e290. doi:10.1371/journal.pmed.0040290. PMC 1989755. PMID 17896862.
cs:Trombóza
de:Thrombose
eo:Trombozo
it:Trombosi
he:תרומבוס
ms:Trombotik
nl:Trombose
fi:Verihiutale