Osteoarthritis causes: Difference between revisions
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==Causes== | ==Causes== | ||
Osteoarthritis often affects multiple members of the same family, suggesting that there is [[hereditary]] susceptibility to this condition. A number of studies have shown that there is a greater prevalence of the disease between siblings and especially [[Twin#Identical twins|identical twins]], indicating a hereditary basis. Up to 60% of OA cases are thought to result from genetic factors. Researchers are also investigating the possibility of [[Allergy|allergies]], [[infection]]s, or [[Mycosis|fungi]] as a cause. There is some evidence that allergies, whether fungal, infectious or systemically induced, may be a significant contributing factor to the appearance of osteoarthritis in a synovial sac. Randomized, controlled studies have shown a 40% reduction in joint degeneration if [[Tetracycline]] derivative antibiotics are taken consistently over time. | Osteoarthritis often affects multiple members of the same family, suggesting that there is [[hereditary]] susceptibility to this condition. A number of studies have shown that there is a greater prevalence of the disease between siblings and especially [[Twin#Identical twins|identical twins]], indicating a hereditary basis. Up to 60% of OA cases are thought to result from genetic factors. Researchers are also investigating the possibility of [[Allergy|allergies]], [[infection]]s, or [[Mycosis|fungi]] as a cause. There is some evidence that allergies, whether fungal, infectious or systemically induced, may be a significant contributing factor to the appearance of osteoarthritis in a synovial sac. Randomized, controlled studies have shown a 40% reduction in joint degeneration if [[Tetracycline]] derivative antibiotics are taken consistently over time. | ||
Obesity may contribute to osteoarthritis of the knee.<ref name="pmid22147711">{{cite journal| author=Nguyen US, Zhang Y, Zhu Y, Niu J, Zhang B, Felson DT| title=Increasing prevalence of knee pain and symptomatic knee osteoarthritis: survey and cohort data. | journal=Ann Intern Med | year= 2011 | volume= 155 | issue= 11 | pages= 725-32 | pmid=22147711 | doi=10.1059/0003-4819-155-11-201112060-00004 | pmc=PMC3408027 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22147711 }} </ref><ref name="pmid10230743">{{cite journal| author=McAlindon TE, Wilson PW, Aliabadi P, Weissman B, Felson DT| title=Level of physical activity and the risk of radiographic and symptomatic knee osteoarthritis in the elderly: the Framingham study. | journal=Am J Med | year= 1999 | volume= 106 | issue= 2 | pages= 151-7 | pmid=10230743 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10230743 }} </ref><ref name="pmid9920009">{{cite journal| author=Hart DJ, Doyle DV, Spector TD| title=Incidence and risk factors for radiographic knee osteoarthritis in middle-aged women: the Chingford Study. | journal=Arthritis Rheum | year= 1999 | volume= 42 | issue= 1 | pages= 17-24 | pmid=9920009 | doi=10.1002/1529-0131(199901)42:1<17::AID-ANR2>3.0.CO;2-E | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9920009 }} </ref> | |||
Leg-length inequality > 1 cm is associated with osteoarthritis of the knee.<ref name="pmid20194234">{{cite journal| author=Harvey WF, Yang M, Cooke TD, Segal NA, Lane N, Lewis CE et al.| title=Association of leg-length inequality with knee osteoarthritis: a cohort study. | journal=Ann Intern Med | year= 2010 | volume= 152 | issue= 5 | pages= 287-95 | pmid=20194234 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20194234 | doi=10.1059/0003-4819-152-5-201003020-00006 }} </ref> | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 03:36, 5 April 2013
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Osteoarthritis causes On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Causes
Osteoarthritis often affects multiple members of the same family, suggesting that there is hereditary susceptibility to this condition. A number of studies have shown that there is a greater prevalence of the disease between siblings and especially identical twins, indicating a hereditary basis. Up to 60% of OA cases are thought to result from genetic factors. Researchers are also investigating the possibility of allergies, infections, or fungi as a cause. There is some evidence that allergies, whether fungal, infectious or systemically induced, may be a significant contributing factor to the appearance of osteoarthritis in a synovial sac. Randomized, controlled studies have shown a 40% reduction in joint degeneration if Tetracycline derivative antibiotics are taken consistently over time.
Obesity may contribute to osteoarthritis of the knee.[1][2][3]
Leg-length inequality > 1 cm is associated with osteoarthritis of the knee.[4]
References
- ↑ Nguyen US, Zhang Y, Zhu Y, Niu J, Zhang B, Felson DT (2011). "Increasing prevalence of knee pain and symptomatic knee osteoarthritis: survey and cohort data". Ann Intern Med. 155 (11): 725–32. doi:10.1059/0003-4819-155-11-201112060-00004. PMC 3408027. PMID 22147711.
- ↑ McAlindon TE, Wilson PW, Aliabadi P, Weissman B, Felson DT (1999). "Level of physical activity and the risk of radiographic and symptomatic knee osteoarthritis in the elderly: the Framingham study". Am J Med. 106 (2): 151–7. PMID 10230743.
- ↑ Hart DJ, Doyle DV, Spector TD (1999). "Incidence and risk factors for radiographic knee osteoarthritis in middle-aged women: the Chingford Study". Arthritis Rheum. 42 (1): 17–24. doi:10.1002/1529-0131(199901)42:1<17::AID-ANR2>3.0.CO;2-E. PMID 9920009.
- ↑ Harvey WF, Yang M, Cooke TD, Segal NA, Lane N, Lewis CE; et al. (2010). "Association of leg-length inequality with knee osteoarthritis: a cohort study". Ann Intern Med. 152 (5): 287–95. doi:10.1059/0003-4819-152-5-201003020-00006. PMID 20194234.