Dysplastic nevus pathophysiology: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
===Microscopy=== | |||
Most dermatologists and dermatopathologists use a system devised by the [[NIH]] for classifying melanocytic lesions. In this classification, a nevus can be defined as benign, having atypia, or being a melanoma. A benign nevus is read as (or understood as) having no cytologic or architectural atypia. An atypical mole is read as having architectural atypia, and having (mild, moderate, or severe) cytologic (melanocytic) atypia.<ref>http://www.labpath.com/new1.html</ref> Usually, cytologic atypia is of more important clinical concern than architectural atypia. Usually, moderate to severe cytologic atypia will require further excision to make sure that the surgical margin is completely clear of the lesion. {{Citation needed|date=July 2011}} | |||
The most important aspect of the biopsy report is that the pathologist indicates if the margin is clear (negative or free of melanocytic nevus), or if further tissue (a second surgery) is required. If this is not mentioned, usually a dermatologist or clinician will require further surgery if moderate to severe cytologic atypia is present - and if residual nevus is present at the surgical margin. | |||
===Associated conditions=== | ===Associated conditions=== | ||
;Atypical Mole Syndrome | ;Atypical Mole Syndrome | ||
Atypical Mole Syndrome is a hereditary condition which causes the person to have a large quantity of moles (often 100 or more) with some dysplastic nevi. This often leads to a higher [[risk]] of [[melanoma]], a serious [[skin cancer]].<ref>Burkhart, C.G MPH, MD. Dysplastic nevus declassified; even the NIH recommends elimination of confusing terminology. SKINmed: Dermatology for the Clinician 2(1):12-13, 2003.</ref> | Atypical Mole Syndrome is a hereditary condition which causes the person to have a large quantity of moles (often 100 or more) with some dysplastic nevi. This often leads to a higher [[risk]] of [[melanoma]], a serious [[skin cancer]].<ref>Burkhart, C.G MPH, MD. Dysplastic nevus declassified; even the NIH recommends elimination of confusing terminology. SKINmed: Dermatology for the Clinician 2(1):12-13, 2003.</ref> | ||
A slight majority of melanomas do ''not'' form in an existing mole, but rather create a new [[growth]] on the skin. Nevertheless, those with more dysplastic nevi are at a higher risk of this type of melanoma occurrence.<ref>D.J. Pope, T. Sorahan, J.R. Marsden, P.M. Ball, R.P. Grimley and I.M. Peck. Benign pigmented nevi in children. Arch of Dermatology 2006;142:1599-1604</ref><ref>D.E. Goldgar, L.A. Cannon-Albright, L.J. Meyer, M.W. Pipekorn, J.J. Zone, M.H. Skolnick. Inheritance of Nevus Number and Size in Melanoma and Dysplastic Nevus Syndrome Kindreds. Journal of the National Cancer Institute 1991 83(23):1726-1733</ref> Such persons need to be checked regularly for any changes in their moles and to note any new ones. | A slight majority of melanomas do ''not'' form in an existing mole, but rather create a new [[growth]] on the skin. Nevertheless, those with more dysplastic nevi are at a higher risk of this type of melanoma occurrence.<ref>D.J. Pope, T. Sorahan, J.R. Marsden, P.M. Ball, R.P. Grimley and I.M. Peck. Benign pigmented nevi in children. Arch of Dermatology 2006;142:1599-1604</ref><ref>D.E. Goldgar, L.A. Cannon-Albright, L.J. Meyer, M.W. Pipekorn, J.J. Zone, M.H. Skolnick. Inheritance of Nevus Number and Size in Melanoma and Dysplastic Nevus Syndrome Kindreds. Journal of the National Cancer Institute 1991 83(23):1726-1733</ref> Such persons need to be checked regularly for any changes in their moles and to note any new ones. | ||
===Video=== | |||
{{#ev:youtube|kpHHtp05ba8}} | |||
==References== | ==References== | ||
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[[Category:Oncology]] | [[Category:Oncology]] | ||
[[Category:Types of cancer]] | [[Category:Types of cancer]] | ||
Revision as of 15:56, 10 April 2013
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Pathophysiology
Microscopy
Most dermatologists and dermatopathologists use a system devised by the NIH for classifying melanocytic lesions. In this classification, a nevus can be defined as benign, having atypia, or being a melanoma. A benign nevus is read as (or understood as) having no cytologic or architectural atypia. An atypical mole is read as having architectural atypia, and having (mild, moderate, or severe) cytologic (melanocytic) atypia.[1] Usually, cytologic atypia is of more important clinical concern than architectural atypia. Usually, moderate to severe cytologic atypia will require further excision to make sure that the surgical margin is completely clear of the lesion. [citation needed]
The most important aspect of the biopsy report is that the pathologist indicates if the margin is clear (negative or free of melanocytic nevus), or if further tissue (a second surgery) is required. If this is not mentioned, usually a dermatologist or clinician will require further surgery if moderate to severe cytologic atypia is present - and if residual nevus is present at the surgical margin.
Associated conditions
- Atypical Mole Syndrome
Atypical Mole Syndrome is a hereditary condition which causes the person to have a large quantity of moles (often 100 or more) with some dysplastic nevi. This often leads to a higher risk of melanoma, a serious skin cancer.[2] A slight majority of melanomas do not form in an existing mole, but rather create a new growth on the skin. Nevertheless, those with more dysplastic nevi are at a higher risk of this type of melanoma occurrence.[3][4] Such persons need to be checked regularly for any changes in their moles and to note any new ones.
Video
{{#ev:youtube|kpHHtp05ba8}}
References
- ↑ http://www.labpath.com/new1.html
- ↑ Burkhart, C.G MPH, MD. Dysplastic nevus declassified; even the NIH recommends elimination of confusing terminology. SKINmed: Dermatology for the Clinician 2(1):12-13, 2003.
- ↑ D.J. Pope, T. Sorahan, J.R. Marsden, P.M. Ball, R.P. Grimley and I.M. Peck. Benign pigmented nevi in children. Arch of Dermatology 2006;142:1599-1604
- ↑ D.E. Goldgar, L.A. Cannon-Albright, L.J. Meyer, M.W. Pipekorn, J.J. Zone, M.H. Skolnick. Inheritance of Nevus Number and Size in Melanoma and Dysplastic Nevus Syndrome Kindreds. Journal of the National Cancer Institute 1991 83(23):1726-1733