Right bundle branch block pathophysiology: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Right bundle branch block}} | {{Right bundle branch block}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}} {{AN}}, {{RT}} | ||
==Pathophysiology== | ==Pathophysiology== | ||
===Normal Conduction=== | ===Normal Conduction=== | ||
# The normal cardiac conduction proceeds in a way so as to allow time for atrium to relax during atrial diastole. | # The normal cardiac conduction proceeds in a way so as to allow time for atrium to relax during atrial [[diastole]]. | ||
# The electrical impulse generated in the [[SA node]] travels through the internodal pathways towards the [[AV node]]. | # The electrical impulse generated in the [[SA node]] travels through the internodal pathways towards the [[AV node]]. | ||
# The conduction through the AV node is slowed down as it travels through it. This decrease in velocity of conduction allows time for atrial to contract ahead of the ventricle so that the blood from the atria can fill up the ventricles through the atrio-ventricular valves. | # The conduction through the AV node is slowed down as it travels through it. This decrease in velocity of conduction allows time for atrial to contract ahead of the ventricle so that the blood from the atria can fill up the ventricles through the atrio-ventricular valves. | ||
# As the impulse flows through the compact AV node, it rapidly conducts through the ventricular myocardial cells. Once the depolarization is complete, the ventricle relaxes during the diastole in preparation for the next impulse. | # As the impulse flows through the compact AV node, it rapidly conducts through the ventricular myocardial cells. Once the depolarization is complete, the ventricle relaxes during the [[diastole]] in preparation for the next impulse. | ||
[[Image:Conduction system of the heart.png|left|thumb|200px|Conduction system of the heart]]<br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /> | [[Image:Conduction system of the heart.png|left|thumb|200px|Conduction system of the heart]]<br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /> | ||
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** Transitional cell zone: This is the region where the internodal atrial pathways merge with the compact AV node. | ** Transitional cell zone: This is the region where the internodal atrial pathways merge with the compact AV node. | ||
** Compact AV node: This region is located at the apex of the [[triangle of Koch]], which is formed by the ostium of [[coronary sinus]], tricuspid annulus and the [[tendon of Todaro]]. | ** Compact AV node: This region is located at the apex of the [[triangle of Koch]], which is formed by the ostium of [[coronary sinus]], tricuspid annulus and the [[tendon of Todaro]]. | ||
** Penetrating portion of the AV bundle: This region enters the tendon of Torado and runs within the fibrous body of the membranous interventricular septum and eventually divides at the crest of the muscular interventricular septum into right and left branches. | ** Penetrating portion of the AV bundle: This region enters the [[tendon of Torado]] and runs within the fibrous body of the [[interventricular septum|membranous interventricular septum]] and eventually divides at the crest of the [[interventricular septum|muscular interventricular septum]] into right and left branches. | ||
* The right bundle branch is the direct continuation of the penetrating bundle of His. It continues along the surface of the right side of the interventricular septum, below the [[papillary muscle|papillary muscle of conus]]. it then proceeds towards the apex and passes through the [[moderator band]] to the base of the [[papillary muscle|anterior papillary muscle]] and then to the free wall of the [[right ventricle]]. | * The right bundle branch is the direct continuation of the penetrating bundle of His. It continues along the surface of the right side of the interventricular septum, below the [[papillary muscle|papillary muscle of conus]]. it then proceeds towards the apex and passes through the [[moderator band]] to the base of the [[papillary muscle|anterior papillary muscle]] and then to the free wall of the [[right ventricle]]. | ||
Revision as of 17:09, 12 April 2013
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aarti Narayan, M.B.B.S [2], Raviteja Guddeti, M.B.B.S. [3]
Pathophysiology
Normal Conduction
- The normal cardiac conduction proceeds in a way so as to allow time for atrium to relax during atrial diastole.
- The electrical impulse generated in the SA node travels through the internodal pathways towards the AV node.
- The conduction through the AV node is slowed down as it travels through it. This decrease in velocity of conduction allows time for atrial to contract ahead of the ventricle so that the blood from the atria can fill up the ventricles through the atrio-ventricular valves.
- As the impulse flows through the compact AV node, it rapidly conducts through the ventricular myocardial cells. Once the depolarization is complete, the ventricle relaxes during the diastole in preparation for the next impulse.
Anatomy
- The conduction system of the heart consists of specialized cells designed to conduct electrical impulse faster than the surrounding myocardial cells.
- Anatomically, the AV node is divided into three regions as follows:
- Transitional cell zone: This is the region where the internodal atrial pathways merge with the compact AV node.
- Compact AV node: This region is located at the apex of the triangle of Koch, which is formed by the ostium of coronary sinus, tricuspid annulus and the tendon of Todaro.
- Penetrating portion of the AV bundle: This region enters the tendon of Torado and runs within the fibrous body of the membranous interventricular septum and eventually divides at the crest of the muscular interventricular septum into right and left branches.
- The right bundle branch is the direct continuation of the penetrating bundle of His. It continues along the surface of the right side of the interventricular septum, below the papillary muscle of conus. it then proceeds towards the apex and passes through the moderator band to the base of the anterior papillary muscle and then to the free wall of the right ventricle.
Genetics
There can be familial cases of right bundle branch block such as that observed in 4 Lebanese families and the abnormality was mapped to chromosome 19. There is a subset of patients with Brugada syndrome who have mutations in SCN5A, the gene encoding for the voltage-gated cardiac sodium channel.
Associated Syndromes
- Duchenne muscular dystrophy
- Myotonic dystrophy: Other ECG findings include first-degree AV block, left anterior fascicular block, and intraventricular conduction delay. Patients may have arrhythmias and/or Stokes-Adams attacks.
- Kearns-Sayre Syndrome
- Brugada syndrome: This syndrome is due to a channelopathy mediated by the SCN5A gene. It is important to note that the RBBB pattern seen in patients with this syndrome is not actually RBBB but is instead due to a repolarization abnormality. In this syndrome, the ECG shows ST-segment elevation in leads V1-V3. Cocaine consumption and / or the use of the antiarrhythmic propafenone may unmask the ECG findings of Brugada syndrome.
Pseudo Right Bundle Branch Block
Brugada syndrome: This syndrome is due to a channelopathy mediated by the SCN5A gene. It is important to note that the RBBB pattern seen in patients with this syndrome is not actually RBBB but is instead due to a repolarization abnormality. It is for this reason that the RBBB like pattern in Brugada syndrome is referred to as a 'pseudo right bundle branch block.' In this syndrome, the ECG shows ST-segment elevation in leads V1-V3. Cocaine consumption and / or the use of the antiarrhythmic propafenone may unmask the ECG findings of Brugada syndrome.